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Table 2 Comparisons of perioperative red blood cell related findings between the two groups

From: Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: a prospective randomized noninferiority trial

Group Intravenous iron Autologous whole blood p
n 32 32
Four weeks before surgery (baseline)
 Hemoglobin (g/dL) 14.5 ± 1.4 14.3 ± 1.4 0.529
 Hematocrit (%) 42.8 ± 3.8 42.5 ± 3.6 0.79
 RBC count (× 1012/L) 4.8 ± 0.4 4.7 ± 0.4 0.491
Red cell index
 MCV (fL) 89.2 ± 3.5 89.3 ± 2.3 0.831
 MCH (pg) 30.1 ± 1.3 30.1 ± 1.0 0.991
 MCHC (%) 33.9 ± 0.9 33.5 ± 0.7 0.09
 Iron (μg/dL) 128.9 ± 48.6 113.3 ± 42.4 0.176
 Ferritin (ng/mL) 105.7 ± 92.9 107.5 ± 77.7 0.932
Immediately before surgery
 Hemoglobin (g/dL) 13.5 ± 1.4*** 12.0 ± 2.0***  < 0.001
 Hematocrit (%) 40.2 ± 2.7*** 35.5 ± 5.5***  < 0.001
 RBC count (× 1012/L) 4.5 ± 0.4*** 4.0 ± 0.6***  < 0.001
Red cell index
 MCV (fL) 89.5 ± 3.4 89.1 ± 3.7 0.617
 MCH (pg) 30.1 ± 1.3 30.0 ± 1.4 0.631
 MCHC (%) 33.8 ± 0.8 33.6 ± 0.7 0.401
 Iron (μg/dL) 98.6 ± 33.0*** 62.2 ± 40.9***  < 0.001
 Ferritin (ng/mL) 271.2 ± 156.4** 66.3 ± 111.6  < 0.001
Postoperative day 1
 Hemoglobin (g/dL) 10.1 ± 1.9*** 10.1 ± 1.8*** 0.849
 Hematocrit (%) 30.1 ± 5.5*** 29.7 ± 4.9*** 0.765
 RBC count (× 1012/L) 3.4 ± 0.6*** 3.4 ± 0.6*** 0.697
Red cell index
 MCV (fL) 89.0 ± 1.7 89.4 ± 3.3 0.542
 MCH (pg) 30.0 ± 0.7 30.0 ± 1.2 0.829
 MCHC (%) 33.7 ± 0.7 33.7 ± 0.8 0.961
 Iron (μg/dL) 40.6 ± 29.8*** 22.7 ± 12.1*** 0.002
 Ferritin (ng/mL) 265.2 ± 161.1*** 102.3 ± 96.2  < 0.001
Postoperative day 2
 Hemoglobin (g/dL) 9.1 ± 1.6*** 9.9 ± 1.4*** 0.035
 Hematocrit (%) 26.9 ± 4.9*** 29.4 ± 4.3*** 0.036
 RBC count (× 1012/L) 3.0 ± 0.6*** 3.3 ± 0.5*** 0.022
Red cell index
 MCV (fL) 89.8 ± 2.5 89.9 ± 3.5 0.823
 MCH (pg) 30.4 ± 1.0 29.9 ± 1.3 0.081
 MCHC (%) 33.9 ± 0.5 33.7 ± 0.7 0.433
 Iron (μg/dL) 63.0 ± 26.4*** 41.4 ± 22.9*** 0.001
 Ferritin (ng/mL) 281.8 ± 150.3*** 107.3 ± 93.5  < 0.001
  1. Values are expressed as mean ± SD and number (proportion)
  2. RBC red blood cell, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, HCHC mean corpuscular hemoglobin concentration
  3. *p < 0.05 based on the level at 4 weeks before surgery (baseline)
  4. **p < 0.01 based on the level at 4 weeks before surgery (baseline)
  5. ***p < 0.001 based on the level at 4 weeks before surgery (baseline)
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