Study, year | No. of patients (no. of lost to follow up) | Periodontal definition | Study methods | Intervention | Outcome measures | Authors’ conclusion |
---|---|---|---|---|---|---|
Fang 2015 | 97 (4) | CAL ≥ 1 mm, including slight, moderate, and severe periodontitis and at least 16 teeth | RCT, 2 groups with ESRD undergoing HD, on average 4 h of HD 3 times a week; 6-week, 3- and 6-month follow-up | T: NSPT, including OHI + SRP at baseline and supragingival prophylaxis at 3 months C: OHI A single certified periodontist | After 3, 6 months, the levels of hs-CRP, IL-6 and Alb significantly decreased (P < 0.05); No significant difference for serum TNF-α, TC, TG, HDL-C, and LDL-C levels; | NSPT can effectively improve periodontal, systemic inflammation and nutritional status in ESRD patients |
Wehmeyer 2014 | 25 (0) | At least 2 teeth with ≥6 mm CAL and at least 1 a site with probing depth > 5 mm | RCT, 2 groups undergoing HD and/or PD; 3- and 6-month follow-up | T: NSPT (OHI + SRP and local minocycline when all sites with PD > 5 mm at the time of SRP and at the 3 and 6 months) C: OHI One of three trained providers | No significantthe difference for serum albumin (Alb) and IL-6 levels in the intervention group at any point period (3 and 6 months) | NSPT did not produce an significant impact on serum systemic inflammation and nutritional markers |
Li 2019 | 72 (0) | At least two sites with CAL ≥ 3 mm and probing depth ≥ 4 mm | RCT, 2 groups undergoing HD, on average 4 h of HD 3 times a week; 8-week follow-up | T: NSPT (OHI+ SRP); C: No treatment No report about who performed the therapy | Hs-CRP levels significantly decreased in the intervention group | NSPT can decrease systemic inflammation through hs-CRP |
Zhang 2017 | 61 (0) | At least 6 sites with CAL ≥ 4 mm and at least 14 teeth | RCT, 2 groups undergoing PD; 4-week follow-up | T: NSPT (OHI+ SRP); C: No treatment No report about who performed the therapy | Hs-CRP levels significantly decreased in the intervention group | NSPT can reduce systemic inflammation through hs-CRP |
Ma 2018 | 98 (0) | At least 2 sites with CAL>3 mm and probing depth>4 mm and at least 20 teeth | RCT, 2 groups undergoing HD, on average 4 h of HD 3 times a week; 6-week follow-up | T: NSPT (OHI+ SRP); C: No treatment No report about who performed the therapy | Hs-CRP levels significantly decreased in intervention group | NSPT can reduce systemic inflammation through hs-CRP |