Fig. 2From: Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratioExpressions of HIF-1α in rat ligation-induced experimental periodontitis. Immunohistochemistry staining showed positive expression of HIF-1α in the region where infiltrating inflammatory cells were localized (a, b, c). Compared with normal gingiva, the gingiva in periodontitis expressed higher HIF-1α according to western blotting (*P < 0.05) (d)Back to article page