Table 2 Meta-analysis of comparison to − 330 T/G polymorphism in Interleukin-2 gene and chronic periodontitis risk (allelic and genotypic comparisons)
Comparison (n) | OR (95% CI) | Pvalue (z test) | I2 | Pheterogeneity | Statistical model used |
|---|---|---|---|---|---|
Overall (n = 5) | |||||
M versus m | 1.34 (0.73, 2.45) | 0.34 | 88% | P < 0.00001 | R |
m versus M | 0.75 (0.41, 1.37) | 0.34 | 88% | P < 0.00001 | R |
MM versus mm | 2.07 (0.76, 5.61) | 0.15 | 81% | 0.001 | R |
mm versus MM | 0.48 (0.18, 1.31) | 0.15 | 81% | 0.001 | R |
MM versus Mm + mm | 2.59 (0.62, 10.85) | 0.19 | 93% | P < 0.00001 | R |
Mm versus MM + mm | 0.70 (0.41, 1.20) | 0.19 | 67% | 0.03 | R |
Caucasian (n = 2) | |||||
M versus m | 0.83 (0.48, 1.44) | 0.52 | NA | – | F |
m versus M | 1.20 (0.69, 2.08) | 0.52 | NA | – | F |
MM versus mm | 1.77 (0.49, 6.46) | 0.39 | NA | – | F |
mm versus MM | 0.56 (0.15, 2.06) | 0.39 | NA | – | F |
MM versus Mm + mm | 2.90 (0.82, 10.27) | 0.10 | NA | – | F |
Mm versus MM + mm | 0.36 (0.17, 0.76) | 0.008 | NA | – | F |
Asian (n = 2) | |||||
M versus m | 1.69 (0.65, 4.42) | 0.28 | 95% | P < 0.00001 | R |
m versus M | 0.59 (0.23, 1.54) | 0.28 | 95% | P < 0.00001 | R |
MM versus mm | 2.58 (1.74, 3.81) | P < 0.00001 | 93% | 0.0001 | R |
mm versus MM | 0.39 (0.26, 0.57) | P < 0.00001 | 93% | 0.0001 | R |
MM versus Mm + mm | 3.18 (0.34, 29.37) | 0.31 | 98% | P < 0.00001 | R |
Mm versus MM + mm | 0.72 (0.36, 1.45) | 0.36 | 72% | 0.06 | R |