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Table 1 Characteristics of included studies in the meta-analysis

From: Periodontitis and inflammatory bowel disease: a meta-analysis

Author (Year)LocationStudy designMatched variablesParticipants (M/F, age)IBD (M/F)Periodontal measuresPharmacological treatmentsSmokingAdjusted variablesNOS
Groessner-Schreiber, et al. (2006)GermanyMatched case–control studyAge;
sex; smoking status
IBD:62 (24/38, 38.4)
Control:59 (24/35, 38.2)
CD:46 (18/28)
UC: 16 (4/12)
PI; BOP; PPD; CAL ≥ 4 mm; CAL ≥ 5 mmCorticosteroids;
immunosuppressants;
aminosalicylate;
anti TNF Antibiotics
IBD
nonsmokers = 34 (55%);
smokers = 25;
ex-smokers = 3 (5%)
Control
nonsmokers =29 (49%);
smokers = 24;
ex-smokers = 6 (10%)
NA7
Zervou, et al. (2007)GreeceMatched case–control studyAge;
sex
IBD:30
Control:47
CD: 15 UC: 15PeriodontitisMesalazine;
aziathioprine
OR (95%CI)
nonsmokers = 1.00;
smokers = 0.99 (0.11–0.63);
ex-smokers = 0.61 (0.06–6.29)
Sex;
smoking habit;
activity duration of disease
6
Brito, et al. (2008)BrazilMatched case–control studyAgeIBD:179 (64/115)
Control:74 (24/50, 40.3)
CD:99 (31/68) UC:80 (33/47)BOP; PPD; CAL ≥ 3 mmAminosalicylates; immunomodulaors; corticosteroidds;
antibiotics;
anti TNF-α
CD
smokers = 12 (12.1%);
nonsmokers = 63 (63.3%);
ex-smokers = 24 (24.3%).
UC
smokers = 7 (8.7%);
nonsmokers = 38 (47.5%);
ex-smokers = 35 (43.8%)
Control
smokers = 9 (12.2%);
nonsmokers = 57 (77%);
ex-smokers = 8 (10.8%)
NA7
Habashneh, et al. (2012)JordanCase–control studyNAIBD:160 (94/66)
Control:100 (62/38)
CD:59 (33/26) UC:101 (61/40)PI; GI; PPD; CAL; GR; BOP; PPD ≥ 3; PPD ≥ 4; CAL ≥ 3; CAL ≥ 4; CAL ≥ 5NACD
nonsmokers = 23;
smokers = 31;
ex-smokers = 5
UC
nonsmokers = 55;
smokers = 17;
ex-smokers = 29
Control
nonsmokers = 44;
smokers = 49;
ex-smokers = 7
NA7
Vavricka, et al. (2013)SwitzerlandMatched case–control studyAgeIBD:113 (65/48, 40.6)
Control:113 (58/55, 41.7)
CD: 69 (37/32)
UC: 44 (28/16)
PPD; CAL; CAL at deepest pocket; BOP; PBISystemic steroids;
aminosalicylates;
Thiopurines;
methotrexate;
cyclosporine; or tacrolimus;
anti-TNF;
probiotics;
nonsteroidal;
antiinflammatory drug
CD
nonsmokers = 25;
smokers = 21;
ex-smokers = 3
UC
nonsmokers = 23;
smokers = 2;
ex-smokers = 19
Control
nonsmokers = 71;
smokers = 21;
ex-smokers = 21
Perianal extraintestinal manifestation; proctitis;
teeth brushing≥twice/day;
ex-smoking; HBI>10;
CD montreal perianal
7
Koutsochristou, et al. (2015)GreeceMatched case–control studyAge;
Sex;
social-economic status
IBD:55 (25/30, 12.3)
Control:55 (25/30, 12.2)
CD: 36 (18/18)UC: 19 (7/12)GI; CPI (PPD)Aminosalicylate;
corticosteroids;
anti-TNF;
immunomodulators
CD
nonsmokers = 36;
UC
nonsmokers = 19;
Control
nonsmokers = 55
NA8