Baseline | p | 6 months | p | 12 months | p | Δ0–6 | p | Δ6–12 | p | Δ0–12 | p | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PD | ||||||||||||
Test | 4.8 ± 0.4 | 4.0 ± 0.4 | 3.7 ± 0.4 | − 0.9 ± 0.2 | < 0.001 | − 0.2 ± 0.2 | 0.331 | − 1.0 ± 0.2 | < 0.001 | |||
Control | 4.6 ± 0.2 | 3.5 ± 0.3 | 3.4 ± 0.3 | − 1.05 ± 0.2 | < 0.001 | − 0.1 ± 0.2 | 0.534 | − 1.2 ± 0.3 | < 0.001 | |||
Difference | 0.2 ± 0.3 | 0.468 | 0.5 ± 0.4 | 0.192 | 0.4 ± 0.4 | 0.232 | 0.20 ± 0.3 | 0.454 | − 0.0 ± 0.3 | 0.901 | 0.2 ± 0.3 | 0.540 |
CAL | ||||||||||||
Test | 5.5 ± 0.4 | 5.2 ± 0.4 | 5.1 ± 0.4 | − 0.3 ± 0.2 | 0.175 | − 0.1 ± 0.2 | 0.502 | − 0.4 ± 0.3 | 0.119 | |||
Control | 5.0 ± 0.2 | 4.4 ± 0.3 | 4.5 ± 0.3 | − 0.6 ± 0.1 | < 0.001 | 0.1 ± 0.1 | 0.584 | − 0.5 ± 0.2 | 0.004 | |||
Difference | 0.5 ± 0.4 | 0.221 | 0.8 ± 0.4 | 0.032 | 0.6 ± 0.4 | 0.097 | 0.3 ± 0.2 | 0.107 | − 0.2 ± 0.2 | 0.404 | 0.2 ± 0.2 | 0.448 |
GCF | ||||||||||||
Test | 79.5 ± 7.5 | 57.3 ± 7.5 | 44.0 ± 7.7 | − 22.2 ± 11.0 | 0.044 | − 14.6 ± 11.2 | 0.171 | − 36.7 ± 11.2 | 0.001 | |||
Control | 78.8 ± 7.5 | 55.1 ± 7.5 | 45.0 ± 7.7 | − 23.7 ± 7.6 | 0.002 | − 10.6 ± 7.7 | 0.171 | − 34.2 ± 7.7 | < 0.001 | |||
Difference | 0.7 ± 8.8 | 0.937 | 2.2 ± 8.8 | 0.804 | − 1.0 ± 9.1 | 0.917 | − 1.5 ± 12.5 | 0.905 | 3.2 ± 12.7 | 0.804 | 1.7 ± 12.7 | 0.897 |