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Table 3 Awareness and management protocol according to prior MRONJ experience

From: The awareness and practice of dentists regarding medication-related osteonecrosis of the jaw and its prevention: a cross-sectional survey

Sex MRONJ experience Pa
No Yes
Male 541 (76.5%) 246 (84.0%) 0.009
Female 166 (23.5%) 47 (16.0%)  
Age (y)    
 ≤ 30 5 (0.7%) 27 (9.2%)  < 0.0001
31–40 226 (32%) 72 (24.6%)  
41–50 350 (49.5%) 116 (39.6%)  
51–60 102 (14.4%) 70 (23.9%)  
 ≥ 61 24 (3.4%) 8 (2.7%)  
Type of practice    
Private clinicb 605 (85.6%) 248 (84.6%) 0.705
Non-private clinicc 102 (14.4%) 45 (15.4%)  
Clinical experience (y)    
 ≤ 5 64 (9.1%) 38 (13%) 0.030
6–10 135 (19.1%) 44 (15%)  
11–15 193 (27.3%) 63 (21.5%)  
16–20 150 (21.2%) 62 (21.2%)  
 ≥ 21 165 (23.3%) 86 (29.4%)  
Do you record if the patient is taking anti-osteoporotic drugs?    
Yes 689 (97.5%) 280 (95.6%) 0.116
No 18 (2.5%) 13 (4.4%)  
Do you record the name of the drug and duration of its use?    
No 115 (16.3%) 72 (24.6%) 0.007
Name only 115 (16.3%) 48 (16.4%)  
Name and duration 477 (67.5%) 173 (59.0%)  
Do you ask for a doctor's referral letter prior to dental surgery procedures?    
Yes 423 (59.8%) 168 (57.3%) 0.466
No 284 (40.2%) 125 (42.7%)  
How long do you advise patients to discontinue the anti-osteoporotic agent before tooth extraction or implant placement?    
 ≤ 2 months 88 (12.4%) 61 (20.8%) 0.001
3–5 months 321 (45.4%) 136 (46.4%)  
 ≥ 6 months 298 (42.1%) 96 (32.8%)  
Do you recommend different drug holidays depending on the type of drug (bisphosphonates, denosumab, SERMs, PTH)?    
Yes 319 (45.1%) 148 (50.5%) 0.120
No 388 (54.9%) 145 (49.5%)  
If you have encountered case/s of MRONJ, what type of medication caused it?    
Bisphosphonates 276 (94.2%)
Denosumab 13 (4.4%)  
SERMs 4 (1.4%)  
No experience 707 (100.0%)  
  1. y, year; MRONJ, medication-related osteonecrosis of the jaw; SERMs, selective estrogen-receptor modulators; PTH, parathyroid hormone
  2. aDifferences between dentists with and those without prior MRONJ experience were evaluated using the χ2 test. The level of statistical significance was set at P < 0.05. Data are presented as N (%)
  3. bDentists engaged in private practice
  4. cEmployed dentists, public dentists, leave of absence, etc.