Effects of immediate and delayed loading protocols on marginal bone loss around implants in unsplinted mandibular implant-retained overdentures: a systematic review and meta-analysis

Liu, Wei; Cai, He; Zhang, Junjiang; Wang, Jian; Sui, Lei

doi:10.1186/s12903-021-01486-3

Table 2 Characteristics of included studies

From: Effects of immediate and delayed loading protocols on marginal bone loss around implants in unsplinted mandibular implant-retained overdentures: a systematic review and meta-analysis

Nr	Study (year of publication)	Study design	Total number of patients	Age (year) Mean ± SD	Edentulous region	Number of implants (per patient)	Implant system	Implant diameter (mm)	Implant length (mm)	Torque of implants (N·cm)	Attachment type	Comparison	Number of patients in ILP/DLP	Loading time of ILP/DLP	Radiographic method	Marginal bone loss (mm) Mean ± SD	Implants failed (at 12 months, implants)
1	Kutkut et al. [45]	RCT	20	≥ 22	Mandible	2	BioHorizons	3.8	12	≥ 35	Locator attachment	Immediate loading	10	Immediately	CBCT	0.85 ± 0.69	0
1	Kutkut et al. [45]	RCT	20	≥ 22	Mandible	2	BioHorizons	3.8	12	≥ 35	Locator attachment	Delayed loading	10	3 months	CBCT	1.33 ± 1.47	0
2	Aunmeungtong et al. [46]	RCT	40	ILP; 66.65 ± 6.28	Mandible	2	PW Plus	ILP; 3.5	ILP; 12	30–55	Ball anchor	Immediate loading	20	Immediately	Panoramic	0.53 ± 0.41	0
2	Aunmeungtong et al. [46]	RCT	40	DLP; 73.8 ± 10.4	Mandible	2	PW Plus	DLP; 3.75	DLP; 10	30–55	Ball anchor	Delayed loading	20	3 months	Panoramic	0.6 ± 0.45	0
3	Schincaglia et al. [47]	RCT	32	ILP; 66.6 ± 10.2	Mandible	2	Astra Tech	4	ILP; 8, 11, 13	≥ 20	Locator attachment	Immediate loading	15	Immediately	CBCT	0.25 ± 0.50	2
3	Schincaglia et al. [47]	RCT	32	DLP; 66.2 ± 8.6	Mandible	2	Astra Tech	4	DLP; 11, 13, 15	≥ 20	Locator attachment	Delayed loading	15	3 months	CBCT	0.54 ± 0.50	0
4	Elsyad et al. [48]	RCT	36	ILP; 60.3 ± 5.01	Mandible	2	Tiologic	3.7; 4.2; 4.8	11; 13; 15	≥ 35	Locator attachment	Immediate loading	16	Immediately	Standardized periapical radiograph	1.05 ± 0.18	2
4	Elsyad et al. [48]	RCT	36	DLP; 58.9 ± 6.69	Mandible	2	Tiologic	3.7; 4.2; 4.8	11; 13; 15	≥ 35	Locator attachment	Delayed loading	17	3 months	Standardized periapical radiograph	0.87 ± 0.13	0
5	Elsyad et al. [49]	RCT	36	ILP; 63.2 ± 2.69	Mandible	2	Spectra system	3.7; 4.7; 5.7	10; 13; 16	NR	Ball anchor	Immediate loading	15	Immediately	CBCT	0.58 ± 0.53	2
5	Elsyad et al. [49]	RCT	36	DLP; 64.6 ± 3.01	Mandible	2	Spectra system	3.7; 4.7; 5.7	10; 13; 16	NR	Ball anchor	Delayed loading	15	3 months	CBCT	0.55 ± 0.42	0
6	Turkyilmaz et al. [51]	Prospective	20	ILP; 62.3 ± 8	Mandible	2	TiUnite	3.75	15	NR	Ball anchor	Immediate loading	10	7 days	Standardized periapical radiograph	0.28 ± 0.26	0
6	Turkyilmaz et al. [51]	Prospective	20	DLP; 63.2 ± 7	Mandible	2	TiUnite	3.75	15	NR	Ball anchor	Delayed loading	10	3 months	Standardized periapical radiograph	0.27 ± 0.30	0
7	De Smet et al. [50]	Prospective	20	ILP; 58 (44–68)	Mandible	3	Nobel Bicon	3.75 to 4	≥ 13	NR	Ball anchor	Immediate loading	9	Immediately	Standardized periapical radiograph	1.07 ± 0.60	4
7	De Smet et al. [50]	Prospective	20	DLP; 64 (33–72)	Mandible	3	Nobel Bicon	3.75 to 4	≥ 13	NR	Ball anchor	Delayed loading	9	3–4 months	Standardized periapical radiograph	0.47 ± 0.60	2

Nr, number; ILP, immediate loading protocol; DLP, delayed loading protocol; RCT, randomized controlled trial; NR, not reported; CBCT, cone beam computed tomography

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ISSN: 1472-6831

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