Table 3 Meta-analysis of PD reduction, CAL gain, and bone fill variables related to two-wall infra-bony defects

Sturb JR et al., 1979

10

1.9

0.5

3

1.5

0.8

0.657

− 0.720, 2.034

Rajesh et al., 2009

10

6.2

1.1

10

4.3

0.27

2.272

1.097, 3.446

Overall effect

Fixed effects: Total N = 33; SMD = 1.555 (95% CI: 0.705, 2.405); t = 3.730; p = 0.001

Random effects: Total N = 33; SMD = 1.489 (95% CI − 0.158, 3.135); t = 1.844; p = 0.075

Test for heterogeneity: Q = 3.707; p = 0.0542; I² = 73.02% (95% CI 0.00%, 93.93%)

Weight (%)

Fixed

Random

44.40

55.60

48.49

51.51

Rajesh et al., 2009

10

5.6

1.2

10

3.3

1.1

0.524

0.812, 3.015

Zafiropoules et al., 2007

4

4.0

0.8

9

4.4

0.8

− 0.465

− 1.711, 0.781

Overall effect

Fixed effects: Total N = 33; SMD = 0.815 (95% CI 0.031, 1.60); t-value = 2.119; p = 0.042

Random effects: Total N = 33; SMD = 0.734 (95% CI − 1.692, 3.159); t-value = 0.617; p = 0.542

Test for heterogeneity: Q = 9.499; p = 0.002; I² = 89.47% (95% CI 60.84%, 97.17%)

Weight (%)

Fixed

Random

53.83

46.17

50.40

49.60

Sturb JR et al., 1979

10

1.2

0.6

3

2.4

1.3

0.674

− 2.922, 0.045

Zafiropoules et al., 2007

4

6.5

1.7

9

7.7

0.8

0.592

− 2.30, 0.306

Overall effect

Fixed effects: Total N = 26; SMD = − 1.189 (95% CI − 2.107, − 0.271); t-value = − 2.673; p = 0.013

Random effects: Total N = 26; SMD = − 1.189 (95% CI − 2.107, − 0.271); t-value = − 2.673; p = 0.013

Test for heterogeneity: Q = 0.2425; p = 0.622; I² = 0.00% (95% CI 0.00%, 0.00%)

Weight (%)

Fixed

Random

43.55

56.45

43.55

56.45