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Table 3 Meta-analysis of PD reduction, CAL gain, and bone fill variables related to two-wall infra-bony defects

From: Effectiveness of beta-tricalcium phosphate in comparison with other materials in treating periodontal infra-bony defects around natural teeth: a systematic review and meta-analysis

PD reduction Group 1 Group 2 SMD 95% confidence interval (CI)
Study Total Mean SD Total Mean SD
Sturb JR et al., 1979 10 1.9 0.5 3 1.5 0.8 0.657 − 0.720, 2.034
Rajesh et al., 2009 10 6.2 1.1 10 4.3 0.27 2.272 1.097, 3.446
Overall effect
Fixed effects: Total N = 33; SMD = 1.555 (95% CI: 0.705, 2.405); t = 3.730; p = 0.001
Random effects: Total N = 33; SMD = 1.489 (95% CI − 0.158, 3.135); t = 1.844; p = 0.075
Test for heterogeneity: Q = 3.707; p = 0.0542; I2 = 73.02% (95% CI 0.00%, 93.93%)
Weight (%)
Fixed Random
44.40
55.60
48.49
51.51
CAL gain Group1 Group2 SMD 95% CI
Study Total Mean SD Total Mean SD
Rajesh et al., 2009 10 5.6 1.2 10 3.3 1.1 0.524 0.812, 3.015
Zafiropoules et al., 2007 4 4.0 0.8 9 4.4 0.8 − 0.465 − 1.711, 0.781
Overall effect
Fixed effects: Total N = 33; SMD = 0.815 (95% CI 0.031, 1.60); t-value = 2.119; p = 0.042
Random effects: Total N = 33; SMD = 0.734 (95% CI − 1.692, 3.159); t-value = 0.617; p = 0.542
Test for heterogeneity: Q = 9.499; p = 0.002; I2 = 89.47% (95% CI 60.84%, 97.17%)
Weight (%)
Fixed Random
53.83
46.17
50.40
49.60
Bone fill Group1 Group2 SMD 95% CI
Study Total Mean SD Total Mean SD
Sturb JR et al., 1979 10 1.2 0.6 3 2.4 1.3 0.674 − 2.922, 0.045
Zafiropoules et al., 2007 4 6.5 1.7 9 7.7 0.8 0.592 − 2.30, 0.306
Overall effect
Fixed effects: Total N = 26; SMD = − 1.189 (95% CI − 2.107, − 0.271); t-value = − 2.673; p = 0.013
Random effects: Total N = 26; SMD = − 1.189 (95% CI − 2.107, − 0.271); t-value = − 2.673; p = 0.013
Test for heterogeneity: Q = 0.2425; p = 0.622; I2 = 0.00% (95% CI 0.00%, 0.00%)
Weight (%)
Fixed Random
43.55
56.45
43.55
56.45
  1. PD pocket depth, SMD standardized mean difference, SD standard deviation, CAL clinical attachment level