Table 4 Meta-analysis of PD reduction, CAL gain, and bone fill variables related to three-wall infra-bony defects

Sturb JR et al., 1979

3

1.9

0.6

3

1.5

0.7

0.667

− 1.361, 2.340

Rajesh et al., 2009

10

3.5

1.2

10

4.5

1.9

0.439

− 1.524, 0.319

Overall effect

Fixed effects: Total N = 26; SMD = − 0.273 (95% CI − 1.029, 0.484); t = − 0.744; p = 0.464

Random effects: Total N = 26; SMD = − 0.172 (95% CI − 1.274, 0.930); t = − 0.322; p = 0.750

Test for heterogeneity: Q = 1.873; p = 0.171; I² = 46.61% (95% CI 0.00%, 0.00%)

Weight (%)

Fixed

Random

30.22

69.78

39.44

60.56

Rajesh et al., 2009

10

5.9

1.2

10

3.8

1.8

1.315

0.315, 2.315

Zafiropoules et al., 2007

25

4.7

0.8

25

4.5

0.7

0.262

− 0.300, 0.824

Overall effect

Fixed effects: Total N = 35; SMD = 0.532 (95% CI 0.051, 1.013); t-value = 2.206; p = 0.031

Random effects: Total N = 35; SMD = 0.718 (95% CI − 0.323, 1.759); t-value = 1.376; p = 0.173

Test for heterogeneity: Q = 3.636; p = 0.056; I² = 72.50% (95% CI 0.00%, 93.81%)

Weight (%)

Fixed

Random

25.65

74.35

43.30

56.70

Sturb JR et al., 1979

3

1.2

0.5

3

2.4

0.6

− 1.734

− 4.015, 0.547

Zafiropoules et al., 2007

25

7.7

0.9

25

6.3

1.1

1.371

0.747, 1.995

Overall effect

Fixed effects: Total N = 56; SMD = 0.983 (95% CI 0.401, 1.565); t-value = 3.388; p = 0.001

Random effects: Total N = 56; SMD = − 0.088 (95% CI − 3.195, 3.019); t-value = − 0.057; p = 0.955

Test for heterogeneity: Q = 12.500; p = 0.0004; I² = 92.00% (95% CI 72.42%, 97.68%)

Weight (%)

Fixed

Random

12.49

87.51

47.00

53.00