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Table 4 Meta-analysis of PD reduction, CAL gain, and bone fill variables related to three-wall infra-bony defects

From: Effectiveness of beta-tricalcium phosphate in comparison with other materials in treating periodontal infra-bony defects around natural teeth: a systematic review and meta-analysis

PD reduction Group 1 Group 2 SMD 95% confidence interval (CI)
Study Total Mean SD Total Mean SD
Sturb JR et al., 1979 3 1.9 0.6 3 1.5 0.7 0.667 − 1.361, 2.340
Rajesh et al., 2009 10 3.5 1.2 10 4.5 1.9 0.439 − 1.524, 0.319
Overall effect
Fixed effects: Total N = 26; SMD = − 0.273 (95% CI − 1.029, 0.484); t = − 0.744; p = 0.464
Random effects: Total N = 26; SMD = − 0.172 (95% CI − 1.274, 0.930); t = − 0.322; p = 0.750
Test for heterogeneity: Q = 1.873; p = 0.171; I2 = 46.61% (95% CI 0.00%, 0.00%)
Weight (%)
Fixed Random
30.22
69.78
39.44
60.56
CAL gain Group 1 Group 2 SMD 95% CI
Study Total Mean SD Total Mean SD
Rajesh et al., 2009 10 5.9 1.2 10 3.8 1.8 1.315 0.315, 2.315
Zafiropoules et al., 2007 25 4.7 0.8 25 4.5 0.7 0.262 − 0.300, 0.824
Overall effect
Fixed effects: Total N = 35; SMD = 0.532 (95% CI 0.051, 1.013); t-value = 2.206; p = 0.031
Random effects: Total N = 35; SMD = 0.718 (95% CI − 0.323, 1.759); t-value = 1.376; p = 0.173
Test for heterogeneity: Q = 3.636; p = 0.056; I2 = 72.50% (95% CI 0.00%, 93.81%)
Weight (%)
Fixed Random
25.65
74.35
43.30
56.70
Bone fill Group 1 Group 2 SMD 95% CI
Study Total Mean SD Total Mean SD
Sturb JR et al., 1979 3 1.2 0.5 3 2.4 0.6 − 1.734 − 4.015, 0.547
Zafiropoules et al., 2007 25 7.7 0.9 25 6.3 1.1 1.371 0.747, 1.995
Overall effect
Fixed effects: Total N = 56; SMD = 0.983 (95% CI 0.401, 1.565); t-value = 3.388; p = 0.001
Random effects: Total N = 56; SMD = − 0.088 (95% CI − 3.195, 3.019); t-value = − 0.057; p = 0.955
Test for heterogeneity: Q = 12.500; p = 0.0004; I2 = 92.00% (95% CI 72.42%, 97.68%)
Weight (%)
Fixed Random
12.49
87.51
47.00
53.00
  1. PD pocket depth, SMD standardized mean difference, SD standard deviation, CAL clinical attachment level