Table 3 The clinical manifestation, treatment, progression and prognosis of reported IgG4-RD in oral and maxillofacial region

Bukhari AF

Female/66

Hard palate SG Parotid gland

Swelling, a boggy consistency and red–purple discoloration

Swelling of SG

Atypical proliferation of lymphocytes and plasma cell

Chest, abdominal pancreas, lung

Kouwenberg

Male/48

Left maxillary alveolar bone maxillary sinus

Hypermobile teeth necrosis of the left maxillary alveolar process

Destruction of left maxillary alveolar bone and pattern maxillary sinus

Numerous plasma cells fibrosis in a storiform

N/D

Gontarz

Male/30

cervical lymph nodes upper alveolar mucosa maxillary sinus

Enlargement of cervical lymph nodes, inflammatory granulation tissues, loosening of tooth

A defect of the alveolar part of the left maxilla

Lymphocytes, plasma cells, many eosinophils

N/D

Gontarz

Male/46

SG

Cirrhosis of SG

Normal

Dense lymphoplasmacytic Infiltrate, stromal fibrosis

N/D

Kojima

Male/62

Maxillary sinus

Facial swelling

Bilateral consolidation with a peribronchial distribution

Lymphocytes, plasma cells, scattered eosinophils

N/D

Kojima

Male/67

Maxillary sinus

Cough, sputum right nasal obstruction

Diffuse bilateral thickening of the mucosa of the maxillary, frontal sinuses

Lymphocytes, plasma cells, scattered eosinophils

N/D

Anand K

Male/56

SG

Dry mouth sensation, neck swelling

Enlargement of SGs

A dense lymphoplasmacytic infiltrate germinal center

N/D

Andrew

Male/56

Hard palate Parotid gland

Erythematous, nontender, bilateral nodules

Enlargement of parotid glands

N/D

N/D

Laco

Female/59

Floor of mouth

Asymptomatic swelling

N/D

Obliterative phlebitis, lymphoid

N/D

Laco

Male/79

Lower left alveolar mucosa

Asymptomatic swelling

N/D

Obliterative phlebitis

N/D

Laco

Male/74

Upper left alveolar mucosa

Asymptomatic swelling

N/D

N/D

N/D

Sun

Male/53

SG

Painless, hard left neck mass, slight dysfunction of salivary secretion

Left swollen SG

Atrophy, abundant lymphocytoplasma cells

Pancreas

Tanaka

Female/64

SG

Swelling of the right submandibular region

Enlargement of the right SG and atrophy of the left SG with a salivary stone

A ratio of IgG4/IgG-positive plasma cells of more than 50%

Kidney and pancreas

Akiyama

Male/60

SG

Swelling of bilateral SGs

Enlarged bilateral SGs

Heavy infiltration of lymphocytes and hyperplastic germinal center formation

Kidney

Abe

Male/77

SG

Bilateral SG swelling

Diffused enlargement of the bilateral SGs

Diffuse infiltration of lymphocytes and plasma cells and more severe periductal fibrosis

Right nasal septum

Abe

Male/62

SG

Swelling hard mass of submandibular region

Diffused enlargement of SGs

Cellular infiltration with lymphocytes, plasma cells, and eosinophils around the ducts

N/D

Ishida

Male/73

Right maxillary sinus parotid gland

Tumor

A tumor with destruction of the surrounding bone tissues in the maxillary sinus

Hyalinized dense fibrosis in the right maxillary sinus and parotid gland

N/D

Ikeda

Female/50

Maxillary sinus

N/D

A soft shadow in the maxillary sinus

Submucosal infiltration of a number of lymphocytes and plasma cells with fibrosis

N/D

Pace

Male/73

Maxillary sinus

Facial swelling

Opacification of the right maxillary sinus and bone destruction

Inflamed collagenous connective tissue, foci of cholesterol crystals

N/D

Wu

Male/63

Cervical lymph nude

Enlarge masses over bilateral posterior neck

Enlarged lymph nodes

Scattered plasma cells and focal penetration of blood vessels in germinal centers

N/D

Wick

Female/61

Facial nerve

Cranial nerve VI and VII palsies

Homogenous enhancing mass

Plasmacytic infiltration, storiform, fibrosis, and phlebitis

Ear

This case

Male/38

Upper and lower gingiva

Swelling of ginigva

Alveolar bone loss

Lymphoplasmacytic infiltration and a storiform pattern of fibrosis

N/D