Table 3 Diagnostic potential of salivary biomarkers between periodontitis patients and healthy subjects
From: Evaluation of salivary biomarkers for the diagnosis of periodontitis
Biomarker | Cut-off value | AUC value | 95% CI | p value | Sensitivity (%) | Specificity (%) | Positive predictive (%) | Negative predictive (%) |
|---|---|---|---|---|---|---|---|---|
Periodontitis versus Healthy (P versus H) | Â | Â | Â | Â | Â | Â | Â | Â |
 IL-1β (pg/ml) | 91.1 | 0.875 | 0.785–0.965 |  < 0.001 | 90.3 | 76.0 | 82.4 | 86.4 |
 MMP-8 (ng/ml) | 594.6 | 0.761 | 0.630–0.892 | 0.001 | 67.7 | 88.0 | 87.5 | 68.8 |
 ICTP (pg/ml) | 625.0 | 0.840 | 0.727–9.953 |  < 0.001 | 80.6 | 88.0 | 89.3 | 78.6 |
 Pg (Ct value) | 13.81 | 0.788 | 0.668–0.908 |  < 0.001 | 87.1 | 56.0 | 71.1 | 77.8 |
Gingivitis versus Healthy (G versus H) | Â | Â | Â | Â | Â | Â | Â | Â |
 IL-1β (pg/ml) | 104.6 | 0.803 | 0.671–0.935 |  < 0.001 | 83.3 | 76.0 | 76.9 | 82.6 |
 MMP-8 (ng/ml) | 583.6 | 0.766 | 0.630–0.903 | 0.001 | 66.7 | 84.0 | 80.0 | 72.4 |
 ICTP (pg/ml) | 585.0 | 0.594 | 0.435–0.754 | 0.252 | 62.5 | 64.0 | 62.5 | 64.0 |
 Pg (Ct value) | 14.17 | 0.687 | 0.534–0.840 | 0.023 | 75.0 | 64.0 | 66.7 | 72.7 |
Peridoontitis versus Gingivitis (P versus G) | Â | Â | Â | Â | Â | Â | Â | Â |
 IL-1β (pg/ml) | 147.6 | 0.657 | 0.490–0.785 | 0.029 | 67.7 | 64.0 | 70.0 | 61.5 |
 MMP-8 (ng/ml) | 670.7 | 0.563 | 0.412–0.714 | 0.419 | 58.1 | 52.0 | 60.0 | 50.0 |
 ICTP (pg/ml) | 676.0 | 0.707 | 0.612–0.783 | 0.002 | 77.4 | 72.0 | 77.4 | 72.0 |
 Pg (Ct value) | 14.88 | 0.698 | 0.555–0.841 | 0.011 | 67.7 | 76.0 | 77.8 | 65.5 |