Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial

Table 2 Post intervention within group mean differences over time in glycemic and periodontal variables

Variables	SRP + MET + OHI (n = 24)	∆	p-value*	SRP + OHI (n = 26)	∆	p-value*	DT + OHI (n = 24)	∆	p-value*
HbA1c (0 m)	9.05 ± 1.70	–	< 0.001	9.05 ± 1.83	–	< 0.001	8.34 ± 1.26	–	0.001
HbA1c (3 m)	7.8 ± 1.25	− 1.25		8.05 ± 1.29	− 1.0		9.03 ± 1.23	0.69
HbA1c (6 m)	7.47 ± 1.19	− 1.58		7.81 ± 1.43	− 1.24		9.65 ± 1.85	1.31
FBG (0 m)	187.5 ± 56.69	–	< 0.001	180.80 ± 52.18	–	0.006	172.66 ± 54.34	–	0.425
FBG (1 m)	177.29 ± 54.70	− 10.21		167.46 ± 53.61	− 13.34		179.41 ± 49.80	6.75
FBG (3 m)	147.71 ± 36.94	− 39.79		151.56 ± 35.80	− 29.24		181.04 ± 55.51	8.38
FBG (6 m)	137.47 ± 44.96	− 50.03		147.79 ± 37.75	− 33.01		189.30 ± 51.81	16.64
Mean BOP% (0 m)	25.79 ± 10.09	–	< 0.001	25.25 ± 8.63	–	< 0.001	22.08 ± 8.02	–	0.661
Mean BOP% (1 m)	13.65 ± 9.40	− 12.14		14.54 ± 6.01	− 10.71		21.81 ± 13.49	− 0.27
Mean BOP% (3 m)	12.88 ± 7.86	− 12.91		11.66 ± 4.95	− 13.59		23.61 ± 12.82	1.53
Mean PPD (0 m)	3.64 ± 0.88	–	< 0.001	3.44 ± 0.95	–	< 0.001	3.04 ± 0.70	–	0.025
Mean PPD (1 m)	2.45 ± 0.41	− 1.19		2.69 ± 0.68	− 0.75		3.17 ± 0.79	0.13
Mean PPD (3 m)	2.29 ± 0.50	− 1.35		2.68 ± 0.82	− 0.76		3.43 ± 0.95	0.39
Mean CAL (0 m)	4.20 ± 0.77	–	< 0.001	3.74 ± 0.94	–	< 0.001	3.55 ± 1.11	–	0.940
Mean CAL (1 m)	3.04 ± 0.57	− 1.16		2.97 ± 0.83	− 0.77		3.55 ± 0.94	0.00
Mean CAL (3 m)	2.96 ± 0.70	− 1.24		2.54 ± 0.76	− 1.2		3.60 ± 0.91	0.05

SRP, scaling root planning; MET, metronidazole; DT, delayed treatment; OHI, oral hygiene instructions
0 m = baseline, 1 m = 1-month, 3 m = 3-months, 6 m = 6-months
∆ Intra-group mean differences between baseline and each follow-up reading
*All Significant p-value < 0.05 measured by RMANOVA have been made bold

ISSN: 1472-6831