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Table 1 Genome-wide studies of dental caries

From: Genome-Wide Association Study (GWAS) of dental caries in diverse populations

Study

Sample size

Dental caries phenotype

Genes

Genome-wide significant associations

Shaffer et al. 2011

1305 white children, age 3–12

Binary affection status in primary dentation

ACTN2, EDARADD, MPPED2, MTR, and LPO

No

Wang et al. 2012

7443 whites

Adult, age 17–89

Permanent decayed, missing, filled surfaces index (DMFS)

RPS6KA2, ISL1, TLR2 RHOU, FZD1, PTK2B, and ADMTS3,

No

Shaffer et al. 2013

920 whites

Adult, ages 18–75

Permanent cluster- based partial DMFS

LYZL2, AJAP1

Yes

   

ABCG2, PKD2, the dentin/bone SCPP sub-family, EDNRA, TJFBR1, NKX2-3, IFT88, TWSG1, IL17D, and SMAD7

No

Zeng et al. 2013

1017 whites

Adult, age 14–56

Permanent decayed and filled teeth (dft) stratified to generate df-pitt and fissures (dfPF)and df-smooth surface (dfSM)

BCOR, BCORL1, INHBA, CXCR1 and CXCR2

No

Zeng et al. 2014

1006 white children, age 3–14

Primary decayed and filled teeth (dft) stratified to generate df-pitt and fissures (dfPF)and df-smooth surface (dfSM)

KPNA4, ITGAL, PLUNC family genes

Yes

   

MPPED2, AJAP, and PRS6KA2

No

Haworth et al. 2018

19,003 Primary analysis; 13,353 Permanent analysis

European ancestry meta-analysis

age 2.5–18

Presence or absence of treated or untreated caries

ALLC, NEDD9 for primary and permanent dentition respectively

Yes

Shungin et al. 2019

GLIDE and UKB (n = 26,792)

DMFS, DFSS, Nteeth

C5orf66, CA12

Yes

   

KRTCAP2, WNT10A, FGF10, HLA, FOXL1, PBX3, MAMSTR

No