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Table 1 Amount of 14C-lidocaine in the palatal mucosa

From: Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

  Lidocaine
Mean ± SD
Lidocaine with epinephrine
Mean ± SD
p value
Sample size 5 5  
Time (min)    
 0.5 371.5 ± 48.4 423.9 ± 71.2 0.210
 2 751.9 ± 133.8 669.8 ± 101.6 0.306
 4 813.5 ± 41.2 612.2 ± 56.2 < 0.001
 7 948.3 ± 104.9 583.7 ± 47.5 < 0.001
 10 1216.6 ± 156.7 658.5 ± 92.0 < 0.001
 20 1040.0 ± 142.8 701.2 ± 109.0 0.003
 30 940.1 ± 144.2 881.0 ± 84.7 0.452
 40 586.8 ± 112.4 1131.3 ± 155.2 < 0.001
 50 481.0 ± 53.2 995.2 ± 156.4 < 0.001
 60 306.6 ± 109.0 621.5 ± 137.7 0.004
  1. Data presented as the mean amount of lidocaine in ng/1 mg mucosa
  2. p value compares lidocaine versus lidocaine with epinephrine
  3. Unpaired t-test was used to compare means
  4. SD standard deviation