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Table 1 Amount of 14C-lidocaine in the palatal mucosa

From: Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

 

Lidocaine

Mean ± SD

Lidocaine with epinephrine

Mean ± SD

p value

Sample size

5

5

 

Time (min)

   

 0.5

371.5 ± 48.4

423.9 ± 71.2

0.210

 2

751.9 ± 133.8

669.8 ± 101.6

0.306

 4

813.5 ± 41.2

612.2 ± 56.2

< 0.001

 7

948.3 ± 104.9

583.7 ± 47.5

< 0.001

 10

1216.6 ± 156.7

658.5 ± 92.0

< 0.001

 20

1040.0 ± 142.8

701.2 ± 109.0

0.003

 30

940.1 ± 144.2

881.0 ± 84.7

0.452

 40

586.8 ± 112.4

1131.3 ± 155.2

< 0.001

 50

481.0 ± 53.2

995.2 ± 156.4

< 0.001

 60

306.6 ± 109.0

621.5 ± 137.7

0.004

  1. Data presented as the mean amount of lidocaine in ng/1 mg mucosa
  2. p value compares lidocaine versus lidocaine with epinephrine
  3. Unpaired t-test was used to compare means
  4. SD standard deviation