Skip to main content

Table 2 Amount of 14C-lidocaine in the palatal bone

From: Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

 

Lidocaine

Mean ± SD

Lidocaine with epinephrine

Mean ± SD

p value

Sample size

5

5

 

Time (min)

   

 0.5

1.8 ± 0.4

1.9 ± 0.5

0.738

 2

3.9 ± 0.6

4.3 ± 0.6

0.378

 4

3.1 ± 0.9

2.9 ± 0.6

0.769

 7

5.2 ± 0.5

3.6 ± 0.9

0.011

 10

10.3 ± 2.2

3.7 ± 0.6

0.002

 20

7.4 ± 0.8

4.4 ± 0.6

< 0.001

 30

4.3 ± 0.8

6.8 ± 0.6

0.001

 40

3.4 ± 0.7

9.9 ± 1.2

< 0.001

 50

2.6 ± 0.6

6.6 ± 0.6

< 0.001

 60

1.7 ± 0.8

3.5 ± 0.8

0.008

  1. Data presented as the mean amount of lidocaine in ng/1 mg bone
  2. p value compares lidocaine versus lidocaine with epinephrine
  3. Unpaired t-test or Welch’s test if unequal variance used to compare means
  4. SD standard deviation