Table 2 Mean ± Standard deviation differences of Escudier et al. scores throughout the study period

Baseline

4.50 ± 2.12^a,b

3.40 ± 1.58^a

4.70 ± 3.09^a

5.90 ± 2.23^a

7.70 ± 4.27^a

8.20 ± 3.94^a

Week 4

3.50 ± 1.78^a,b

2.10 ± 1.00^b

3.30 ± 2.91^a,b

3.10 ± 2.51^b

4.40 ± 3.37^a,b

3.10 ± 2.b^b

Week 8

3.30 ± 1.83^a,b

1.90 ± 0.88^b

1.70 ± 1.95^b

2.30 ± 1.70^b

2.00 ± 2.26^b

2.30 ± 1.70^b

Friedman test p value

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*

p < 0.001*