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Table 5 Logistic regression of risk factors of colonization throughout the treatment

From: An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study

Patient characteristics Univariate Multivariate
OR (95 %CI) p value OR (95 %CI) p value
Sex     
   Male 1    
 Female 1.42 (0.49–4.12) 0.523   
Age 1.03 (0.99–1.08) 0.168* 1.06 (1.01–1.123) 0.021#
Underlying disease     
 DM 0.52 (0.08–3.36) 0.496   
 HT 0.78 (0.27–2.23) 0.641   
Tumor site     
 Nasopharynx 1    
 Oropharynx 1.10 (0.33–3.60) 0.880   
 Oral cavity 0.84 (0.26–2.69) 0.770   
Radiotherapy option     
 Postoperative RT 1    
 Radical RT 1.15 (0.42–3.14) 0.790   
Dose of radiotherapy (Gy) 1.08(1.01–1.16) 0.031*   
CCRT 3.41 (1.16–9.99) 0.026* 4.29 (1.12–16.49) 0.034#
CCRT cycle 1.06 (0.64–1.78) 0.820   
Type of chemotherapy agent     
 Cisplatin 1    
 Carboplatin 1.16 (0.36–3.80) 0.798   
Personal history     
 Smoking     
  Never used 1    
  Using currently 0.82 (0.26–2.56) 0.727   
 Alcohol     
  Never used 1    
  Using urrently 1.54 (0.58–4.09) 0.387   
Oral status     
 Oral hygiene     
  Excellent/good 1    
  Fair/poor 0.68 (0.20–2.25) 0.527   
 Denture wearer 0.41 (0.10–1.68) 0.216   
Mouthwash using     
 Non-benzydamine HCl 1    
 Benzydamine HCl 1.05 (0.35–3.10) 0.934   
2% viscous lidocaine solution using 2.91 (1.03–8.18) 0.043* 3.62 (1.15–11.34) 0.027#
Xerostomia 3.51 (0.74–16.70) 0.115*   
Mucositis 2.85 (1.01–8.03) 0.048*   
Candida colonization before RT 4.32 (1.32–14.14) 0.016*   
  1. *p < 0.25, # significant risk factors