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Table 6 Logistic regression of risk factors of clinical candidiasis throughout the treatment

From: An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study

Patient characteristics Univariate Multivariate
OR (95 %CI) p value OR (95 %CI) p value
Sex   0.038* 10.93 (2.26–52.86) 0.003#
 Male 1    
 Female 2.71 (1.06–6.95)    
Age 1.02 (0.98–1.07) 0.269   
Underlying disease     
 DM 2.45 (0.39–15.52) 0.341   
 HT 1.27 (0.48–3.36) 0.629   
Tumor site     
 Nasopharynx 1    
 Oropharynx 1.16 (0.38–3.55) 0.790   
 Oral cavity 3.05 (1.04-9.00) 0.043   
Radiotherapy option     
 Postoperative RT     
 Radical RT 1
0.51 (0.20–1.29)
0.158*   
Dose of radiotherapy (Gy) 0.90 (0.81–1.01) 0.066*   
CCRT 1.72 (0.55–5.45) 0.354   
CCRT cycle 0.34 (0.54–1.29) 0.419   
Type of chemotherapy agent     
 Cisplatin 1    
 Carboplatin 0.63 (0.24–1.68) 0.357   
Personal history     
 Smoking     
  Never used 1    
  Using currently 2.56 (0.83–7.85)    
 Alcohol     
  Never used 1 0.100*   
  Using currently 0.68 (0.28–1.67) 0.400 12.57 (2.19–72.29) 0.005#
Oral status     
 Oral hygiene     
  Excellent/good 1    
  Fair/poor 0.57 (0.16–1.98) 0.373   
 Denture wearer 0.75 (0.17–3.23) 0.700   
Mouthwash using     
 Non-benzydamine HCl 1    
 Benzydamine HCl 0.44 (0.15–1.28) 0.133*   
2% viscous lidocaine solution using 2.03 (0.74–5.58) 0.172*   
Xerostomia 2.03 (0.72–5.71) 0.180*   
Mucositis 4.13 (1.60-10.69) 0.003*   
Candida colonization before RT 2.13 (0.87–5.21) 0.100*   
  1. *p < 0.25, #significant risk factors