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Table 2 Efficacy endpoints: Difference in adjusted mean scores between Test and Control groups (mITT population)

From: A randomised clinical study investigating efficacy of a stannous fluoride toothpaste in improving gingival health after 3 weeks’ use

  Differencea (95% CI) p value % Diffb
Bleeding Index score    
 Week 2  − 0.07 (− 0.09, − 0.05)  < 0.0001 32.7%
 Week 3  − 0.06 (− 0.08, − 0.04)  < 0.0001 29.2%
Number of bleeding sites    
 Week 2  − 10.4 (− 13.3, − 7.5)  < 0.0001 33.0%
 Week 3  − 8.2 (− 11.1, − 5.3)  < 0.0001 29.3%
Modified Gingival Index score    
 Week 2  − 0.09 (− 0.13, − 0.06)  < 0.0001 4.3%
 Week 3  − 0.10 (− 0.14, − 0.06)  < 0.0001 4.7%
Overall Turesky Plaque Index score    
 Week 2  − 0.45 (− 0.55, − 0.35)  < 0.0001 16.0%
 Week 3  − 0.42 (− 0.53, − 0.30)  < 0.0001 15.1%
Interproximal Turesky Plaque Index score    
 Week 2  − 0.42 (− 0.52, − 0.33)  < 0.0001 14.6%
 Week 3  − 0.41 (− 0.52, − 0.29)  < 0.0001 14.1%
  1. aFrom ANCOVA analysis; difference is Test toothpaste minus Control toothpaste; a negative difference favours the Test toothpaste
  2. bPercentage difference between group scores calculated as (treatment difference/adjusted mean of reference treatment)*100%