Table 2 Efficacy endpoints: Difference in adjusted mean scores between Test and Control groups (mITT population)

Bleeding Index score

 Week 2

 − 0.07 (− 0.09, − 0.05)

 < 0.0001

32.7%

 Week 3

 − 0.06 (− 0.08, − 0.04)

 < 0.0001

29.2%

Number of bleeding sites

 Week 2

 − 10.4 (− 13.3, − 7.5)

 < 0.0001

33.0%

 Week 3

 − 8.2 (− 11.1, − 5.3)

 < 0.0001

29.3%

Modified Gingival Index score

 Week 2

 − 0.09 (− 0.13, − 0.06)

 < 0.0001

4.3%

 Week 3

 − 0.10 (− 0.14, − 0.06)

 < 0.0001

4.7%

Overall Turesky Plaque Index score

 Week 2

 − 0.45 (− 0.55, − 0.35)

 < 0.0001

16.0%

 Week 3

 − 0.42 (− 0.53, − 0.30)

 < 0.0001

15.1%

Interproximal Turesky Plaque Index score

 Week 2

 − 0.42 (− 0.52, − 0.33)

 < 0.0001

14.6%

 Week 3

 − 0.41 (− 0.52, − 0.29)

 < 0.0001

14.1%