| Jensen et al. [11] | Chong et al. [12] | Platt and Wannfors [13] | Lindeboom et al. [14] | Walivaara etal. [16] | Walivaara et al. [17] | Zhou et al. [21] | ||
---|---|---|---|---|---|---|---|---|---|
Trial design: | RCT | RCT | RCT | RCT | RCT | RCT | RCT | RCT | RCT |
Location: | Denmark | London | Sweden | Netherland | Denmark | Sweden | Sweden | Korea | China |
Recruitment period: | ? | ? | ? | 1/2000 –12/2002 | ? | ? | 9/2006 –12/208 | 2/2003–10/2010 | 12/2012–2/2015 |
Source of funding: | ? | √ | ? | √ | √ | ? | ? | √ | ? |
Ethical approval | √ | √ | √ | √ | √ | ? | ? | √ | √ |
Informed consent | ? | ? | ? | ? | √ | ? | ? | √ | √ |
Eligibility criteria | IC | √ | IC | √ | IC | IC | IC | √ | √ |
Number of surgeons | 4 | 2 | 1 | 3 | 1 | 2 | 2 | 1 | 1 |
Blindness of the patients/operator/ evaluator | ?/ × /√ | ?/?/√ |  × / × /? | √/?/√ | ?/ × /? | ?/ × /? | ?/ × /? | ?/ × /√ | ?/?/√ |
Sample size | 134Pt/134T | 183 Pt/183T | 28 Pt/34T | 90Pt/100T | 44Pt/52T | 139Pt/160T | 164 Pt/206T | 260Pt/260T | 240Pt/240T |
S.S cal | √ | √ |  ×  | √ |  ×  |  ×  |  ×  | √ | √ |
After 1Â year F. up | 122Pt/122T | 122 Pt/122Â T | 28 Pt/34Â T | 90 Pt/100Â T | 39 Pt/46Â T | 131pt/147Â T | 153pt/194Â T | 192Pt/192Â T | 120Pt/120Â T |
More than 1 years F. up |  ×  |  ×  |  ×  |  ×  | 39 teeth 6 years |  ×  | 12–21 Month | 182 4 years |  ×  |
Drop out | 12Pt/12 T | 61 Pt/61 T |  ×  |  ×  | 5 Pt/6 T(1Y) 13 teeth (6Y) | 8 Pt/13 T | 9 Pt/12 T | 68Pt (1Y) 10Pt (4Y) | 82 Pt/82 T |
Age at baseline | Age range of 49 | ? | 33–83 | 17–64 Average 43.4 | Range 30–77 years mean 54.6 | Average 58.5 | – |  ≤ 20 and ≥ 60 Frequency per age range |  ≤ 45 = 136, > 45 = 22 |
Gender | F/M ratio = 1.8:1 | ? | 45% Female | 57 F/33 M | 24F/20 M | 81 F/58 M | 99 F/65 M | 69 F/123 M | 94 F/64 M |
Smokers | 48% | ? | ? | ? | 16/44 | ? | ? | ? | ? |
Clinical variables analysis | √ |  ×  | IC |  ×  | √ |  ×  | IC | IC | √ |
Teeth treated | Max 27Ant 39Pm16 M Mand 6 Ant, 16Pm, 30Â M | Ant teeth 1st PM, MB root of molar | Ant teeth | Single rooted ant teeth and PM | Max 17 incisors/24 canines and PM Mand 11 canines and PM | 46 Incisor 10 Canine 42 PM 49Â M | 40 Incisor 16 Canine 57 PM 81Â M | Max 73 Ant 31 PM 28Â M Mand 21Ant, 11 PM, 28Â M | Ant 113 PM 19 M 26 |
Size of lesion |  < 5 mm = 52, 5–10 mm = 35, > 10 mm = 6 | ? | ? | not > 10 mm | ? | ? |  < 5 mm = 56, 5–9 mm = 102, > 9 mm = 36 | ? | Not > 10 mm |
Use of magnification |  ×  | √ |  ×  | √ | √ | √ | √ | √ | √ |
Use of ultrasonic preparation |  ×  | √ |  ×  | √ | √ | √ | √ | √ | √ |
Angel of resection (bevelling) | √ |  ×  | √ | √ |  ×  | √ | √ |  ×  |  ×  |
Antibiotics prophylaxis | √ | √ |  ×  |  ×  | √ |  ×  |  ×  | √ |  ×  |
Comparison | Retro Plast CS GI | MTA versus IRM | Compomer Dyract versus Ketac Silver GI | MTA versus IRM | (MTA) versus smoothening of orthograde gutta-percha root filling | Ultrafill Gutta Percha versus IRM | IRM versus super EBA | MTA versus super EBA | MTA versus I root Bp plus |