|
Condition
|
SNP and experimental concentration
|
Genotypes median (minimum–maximum)
|
p values
|
|---|
|
Co-dominant modela
|
Recessive modelb
|
|---|
|
No pressure
|
FokI rs2228570 (G > A)
|
GG (n = 12)
|
GA (n = 6)
|
AA (n = 9)
|
|---|
| |
0 ng/ml
|
0.91 (0.01–1.56)
|
0.98 (0.52–1.64)
|
1.02 (0.45–1.58)
|
0.967
|
0.897
|
| |
40 ng/ml
|
0.85 (0.46–1.77)
|
0.56 (0.42–0.96)
|
0.84 (0.28–1.44)
|
0.173
|
0.439
|
| |
BglI rs739837 (G > T)
|
GG (n = 9)
|
GT (n = 6)
|
TT (n = 12)
| | |
|---|
| |
0 ng/ml
|
1.01 (0.45–1.58)
|
1.06 (0.74–1.56)
|
1.03 (0.52–1.64)
|
0.852
|
0.892
|
| |
40 ng/ml
|
0.59 (0.28–0.96)
|
0.95 (0.81–1.77)
|
0.85 (0.42–1.44)
|
0.061
|
0.038*
|
| |
ApaI rs7975232 (A > C)
|
AA (n = 12)
|
AC (n = 9)
|
CC (n = 6)
| | |
|---|
| |
0 ng/ml
|
1.03 (0.52–1.64)
|
1.01 (0.75–1.56)
|
1.09 (0.45–1.58)
|
0.943
|
0.922
|
| |
40 ng/ml
|
0.85 (0.42–1.44)
|
0.84 (0.53–1.77)
|
0.54 (0.28–0.96)
|
0.152
|
0.062
|
|
Pressure
|
FokI rs2228570 (A > G)
|
GG (n = 12)
|
GA (n = 6)
|
AA (n = 9)
| | |
|---|
| |
0 ng/ml
|
0.82 (0.49–1.72)
|
1.20 (0.64–3.14)
|
0.72 (0.47–1.58)
|
0.248
|
0.764
|
| |
40 ng/ml
|
0.59 (0.21–0.90)
|
0.92 (0.60–1.39)
|
0.84 (0.18–1.15)
|
0.122
|
0.235
|
| |
BglI rs739837 (G > T)
|
GG (n = 9)
|
GT (n = 6)
|
TT (n = 12)
| | |
|---|
| |
0 ng/ml
|
0.69 (0.47–2.14)
|
0.74 (0.49–1.56)
|
0.86 (0.49–1.72)
|
0.709
|
0.451
|
| |
40 ng/ml
|
0.88 (0.18–1.38)
|
0.68 (0.26–0.90)
|
0.72 (0.21–1.15)
|
0.601
|
0.398
|
| |
ApaI rs7975232 (A > C)
|
AA (n = 12)
|
AC (n = 9)
|
CC (n = 6)
| | |
|---|
| |
0 ng/ml
|
0.86 (0.49–1.72)a,b
|
0.58 (0.47–1.56)a
|
1.29 (0.54–3.14)b
|
0.045*
|
0.048*
|
| |
40 ng/ml
|
0.73 (0.21–1.15)
|
0.77 (0.26–0.98)
|
0.99 (0.19–1.38)
|
0.683
|
0.581
|
- *Means statistically significant difference (p < 0.05). Comparisons were performed among genotypes within the same SNP under the same experimental conditions. Different letters indicate a significant difference
- aKruskal–Wallis with Dunn’s test was used
- bMann–Whitney test was used
