Table 1 VDR mRNA expression [median (minimum–maximum)] according to the genotypes in each studied SNP in VDR
Condition | SNP and experimental concentration | Genotypes median (minimum–maximum) | p values | |||
|---|---|---|---|---|---|---|
Co-dominant modela | Recessive modelb | |||||
No pressure | FokI rs2228570 (G > A) | GG (n = 12) | GA (n = 6) | AA (n = 9) | ||
0 ng/ml | 0.91 (0.01–1.56) | 0.98 (0.52–1.64) | 1.02 (0.45–1.58) | 0.967 | 0.897 | |
40 ng/ml | 0.85 (0.46–1.77) | 0.56 (0.42–0.96) | 0.84 (0.28–1.44) | 0.173 | 0.439 | |
BglI rs739837 (G > T) | GG (n = 9) | GT (n = 6) | TT (n = 12) | |||
|---|---|---|---|---|---|---|
0 ng/ml | 1.01 (0.45–1.58) | 1.06 (0.74–1.56) | 1.03 (0.52–1.64) | 0.852 | 0.892 | |
40 ng/ml | 0.59 (0.28–0.96) | 0.95 (0.81–1.77) | 0.85 (0.42–1.44) | 0.061 | 0.038* |
ApaI rs7975232 (A > C) | AA (n = 12) | AC (n = 9) | CC (n = 6) | |||
|---|---|---|---|---|---|---|
0 ng/ml | 1.03 (0.52–1.64) | 1.01 (0.75–1.56) | 1.09 (0.45–1.58) | 0.943 | 0.922 | |
40 ng/ml | 0.85 (0.42–1.44) | 0.84 (0.53–1.77) | 0.54 (0.28–0.96) | 0.152 | 0.062 |
Pressure | FokI rs2228570 (A > G) | GG (n = 12) | GA (n = 6) | AA (n = 9) | ||
|---|---|---|---|---|---|---|
0 ng/ml | 0.82 (0.49–1.72) | 1.20 (0.64–3.14) | 0.72 (0.47–1.58) | 0.248 | 0.764 | |
40 ng/ml | 0.59 (0.21–0.90) | 0.92 (0.60–1.39) | 0.84 (0.18–1.15) | 0.122 | 0.235 |
BglI rs739837 (G > T) | GG (n = 9) | GT (n = 6) | TT (n = 12) | |||
|---|---|---|---|---|---|---|
0 ng/ml | 0.69 (0.47–2.14) | 0.74 (0.49–1.56) | 0.86 (0.49–1.72) | 0.709 | 0.451 | |
40 ng/ml | 0.88 (0.18–1.38) | 0.68 (0.26–0.90) | 0.72 (0.21–1.15) | 0.601 | 0.398 |
ApaI rs7975232 (A > C) | AA (n = 12) | AC (n = 9) | CC (n = 6) | |||
|---|---|---|---|---|---|---|
0 ng/ml | 0.86 (0.49–1.72)a,b | 0.58 (0.47–1.56)a | 1.29 (0.54–3.14)b | 0.045* | 0.048* | |
40 ng/ml | 0.73 (0.21–1.15) | 0.77 (0.26–0.98) | 0.99 (0.19–1.38) | 0.683 | 0.581 |