Does arch length preservation in mixed dentition children affect mandibular second permanent molar eruption? A systematic review and meta-analysis

Table 6 GRADE evidence profile [gradepro.org]

Outcomes	No of participants (studies) follow up	Quality of the evidence (GRADE)	Relative effect (95% CI)	Anticipated absolute effects
Outcomes	No of participants (studies) follow up	Quality of the evidence (GRADE)	Relative effect (95% CI)	Risk with control	Risk difference with D (95% CI)
Mandibular second molar eruption disturbance	444 (2 studies)	⊕ ⊝ ⊝ ⊝	OR 5.2 (1.92 to 14.06)	Study population
		VERY LOW^a due to imprecision		22 per 1000	81 more per 1000 (from 19 to 215 more)
				Moderate*
				20 per 1000	76 more per 1000 (from 18 to 203 more)

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate
CI confidence interval, OR odds ratio
^aIndirectness: the 95% CI is too wide so, downgraded by one level
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)

ISSN: 1472-6831