Table 5 The predicted targets of RAS treatment for each compound
Molecule | Gene |
|---|---|
Genistein | STAT1/ICAM1/VCAM1/SOD2/CRYAB/C3/SELE |
Daidzein | STAT1/ICAM1/VCAM1/SOD2/IL6/C3/CAMK4/CSF2RB/HCK/HLA-B/HLA-E/IFNGR1/INHBA/LTF/MSN/NT5C3A/PANK1/THBS1/TPK1 |
Quercetin | STAT1/ICAM1/VCAM1/SELE/CYP1B1/NQO1/IRF1/CAMK4/CSF2RB/HCK/HLA-B/HLA-E/HLA-G/HMGCS1/IFNGR1/LTF/LYZ/MMP1/MMP9/NPR3/NT5C3A/PANK1/THBS1/TLR1/MMP3/IL6 |
Kaempferol | STAT1/ICAM1/VCAM1/SELE/CYP1B1/C3/CD74/GZMB/HLA-E/IFNGR1/IL10RA/LTF/MS4A1/MSN/THBS1/THBS2/TPK1/WARS1 |
Resveratrol | IL6/STAT1/ICAM1/SELE/VCAM1/SOD2/CYP1B1/NQO1/BIRC3/C1R/C3/CSF2RB/HCK/HLA-E/ME1/MSN/NPR3/SAMHD1/TLR1 |
(-)-Epigallocatechin-3-gallate | IL6/MMP3/STAT1/TLR4/BTK/C3/CAMK4/FAP/GCH1/GLUL/GZMB/GZMK/HCK/HLA-B/HLA-E/HMGCS1/IFNGR1/KLF10/LTF/MMP1/MSN/NT5C3A/PANK1/PLA2G2A/THBS1/TRIM21/WARS1 |
Rosmarinic Acid | STAT1/IDO1/ALOX12/ANXA1/BTK/CD38/HCK/HLA-E/LAP3/LYZ/MS4A1/NT5C3A/RGS18/SOD2/TPK1/TRIM21 |
Triptolide | STAT1/CXCR4/BIRC3/CCR7/ALOX12/ANXA1/BTK/CAMK4/GBP1/HLA-E/HMGCS1/LAP3/LTF/MS4A1/MSN/PLA2G2A/RGS18/SOD2/TPK1/TRIM21/WARS1 |