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Table 3 Alleles and genotypes frequencies for NTRK2 c.1397-31392G > A (rs1867283) polymorphism in studied groups

From: Polymorphic variants in genes related to stress coping are associated with the awake bruxism

  NTRK2 c.1397-31392G > A (rs1867283)
Genotype frequencies (%) Allele frequencies (%)
GG
n (%)
GA
n (%)
AA
n (%)
G
n (%)
A
n (%)
Patients with AB
n = 104
32 (31.4%) 52 (49.0%) 20 (19.6%) 116 (55.7%) 92 (44.2%)
Males (n = 26) 10 (38.5%) 10 (38.5%) 6 (23.0%) 30 (57.7%) 22 (42.3%)
Females (n = 78) 22 (28.2%) 42 (53.8%) 14 (18.0%) 86 (55.1%) 70 (44.9%)
Control group (C) (n = 191) 41 (21,5%) 99 (51,8%) 51 (26,7%) 181 (47.4%)
*1000Genomes: 50.0%
201 (52.6%)
*1000Genomes: 50.0%
Control males
(n = 96)
24 (25%) 42 (44%) 30 (31%) 90 (46.9%) 102 (53.1%)
Control females
(n = 95)
17 (17.9%) 57 (60%) 21 (22.1%) 91 (47.9%) 99 (52.1%)
Comparisons of allelic and genotypic frequencies between groups under the study
  [GG + GA]vs[AA] [GG]vs[GA + AA] [GG]vs[AA] [G]vs[A] [A]vs[G]
AB versus C
OR, 95% CI
P value
OR = 0.65
[0.37–1.17]
P = 0.152
OR = 1.63
[0.95–2.79]
P = 0.077
OR = 1.99
[1.00–3.98]
P = 0.050
OR = 1.40
[1.00–1.97]
OR = 0.71
[0.51–1.00]
P = 0.052
AB males versus C males
OR, 95% CI
P value
OR = 0.66
[2.41–1.81]
P = 0.417
OR = 1.86
[0.75–4.68]
P = 0.175
OR = 2.08
[0.66–6.55]
P = 0.204
OR = 1.55
[0.83–2.87]
OR = 0.65
[0.35–1.20]
P = 0.166
AB females** versus C females
OR, 95% CI
P value
OR = 0.77
[0.36–1.64]
P = 0.498
OR = 1.80
[0.88–3.70]
P = 0.106
OR = 1.94
[0.77–4.90]
P = 0.159
OR = 1.34
[0.87–2.04]
OR = 0.75
[0.49–1.14]
P = 0.181
AB females** versus AB males
OR, 95% CI
P value
OR = 0.73
[0.25–2.15]
P = 0.566
OR = 0.63
[0.25–1.60]
P = 0.326
OR = 0.94
[0.28–3.17]
P = 0.924
OR = 0.90
[0.48–1.70]
OR = 1.11
[0.59–2.09]
P = 0.747
C females versus C males
OR, 95% CI
P value
OR = 1.01
[0.28–3.61]
P = 0.987
OR = 0.67
[0.37–1.19]
P = 0.167
OR = 0.84
[0.23–3.06]
P = 0.793
OR = 0.76
[0.47–1.22]
OR = 1.33
[0.82–2.14]
P = 0.215
  1. In bold were marked borderline statistically significant results (P-value < 0.05). No corrections for the multiple statistical testing were made
  2. [GG + GA] versus [AA]—dominant model, risk allele: G
  3. [GG] versus [GA + AA]—recessive model, risk allele: A
  4. *Allele frequencies for the European population according to the 1000Genomes Project have been gathered from http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=9:87450266-87451266;v=rs1867283;vdb=variation;vf=1303363 website
  5. **HWE analysis revealed discordance in the group of females with AB