Skip to main content

Table 3 Alleles and genotypes frequencies for NTRK2 c.1397-31392G > A (rs1867283) polymorphism in studied groups

From: Polymorphic variants in genes related to stress coping are associated with the awake bruxism

 

NTRK2 c.1397-31392G > A (rs1867283)

Genotype frequencies (%)

Allele frequencies (%)

GG

n (%)

GA

n (%)

AA

n (%)

G

n (%)

A

n (%)

Patients with AB

n = 104

32 (31.4%)

52 (49.0%)

20 (19.6%)

116 (55.7%)

92 (44.2%)

Males (n = 26)

10 (38.5%)

10 (38.5%)

6 (23.0%)

30 (57.7%)

22 (42.3%)

Females (n = 78)

22 (28.2%)

42 (53.8%)

14 (18.0%)

86 (55.1%)

70 (44.9%)

Control group (C) (n = 191)

41 (21,5%)

99 (51,8%)

51 (26,7%)

181 (47.4%)

*1000Genomes: 50.0%

201 (52.6%)

*1000Genomes: 50.0%

Control males

(n = 96)

24 (25%)

42 (44%)

30 (31%)

90 (46.9%)

102 (53.1%)

Control females

(n = 95)

17 (17.9%)

57 (60%)

21 (22.1%)

91 (47.9%)

99 (52.1%)

Comparisons of allelic and genotypic frequencies between groups under the study

 

[GG + GA]vs[AA]

[GG]vs[GA + AA]

[GG]vs[AA]

[G]vs[A]

[A]vs[G]

AB versus C

OR, 95% CI

P value

OR = 0.65

[0.37–1.17]

P = 0.152

OR = 1.63

[0.95–2.79]

P = 0.077

OR = 1.99

[1.00–3.98]

P = 0.050

OR = 1.40

[1.00–1.97]

OR = 0.71

[0.51–1.00]

P = 0.052

AB males versus C males

OR, 95% CI

P value

OR = 0.66

[2.41–1.81]

P = 0.417

OR = 1.86

[0.75–4.68]

P = 0.175

OR = 2.08

[0.66–6.55]

P = 0.204

OR = 1.55

[0.83–2.87]

OR = 0.65

[0.35–1.20]

P = 0.166

AB females** versus C females

OR, 95% CI

P value

OR = 0.77

[0.36–1.64]

P = 0.498

OR = 1.80

[0.88–3.70]

P = 0.106

OR = 1.94

[0.77–4.90]

P = 0.159

OR = 1.34

[0.87–2.04]

OR = 0.75

[0.49–1.14]

P = 0.181

AB females** versus AB males

OR, 95% CI

P value

OR = 0.73

[0.25–2.15]

P = 0.566

OR = 0.63

[0.25–1.60]

P = 0.326

OR = 0.94

[0.28–3.17]

P = 0.924

OR = 0.90

[0.48–1.70]

OR = 1.11

[0.59–2.09]

P = 0.747

C females versus C males

OR, 95% CI

P value

OR = 1.01

[0.28–3.61]

P = 0.987

OR = 0.67

[0.37–1.19]

P = 0.167

OR = 0.84

[0.23–3.06]

P = 0.793

OR = 0.76

[0.47–1.22]

OR = 1.33

[0.82–2.14]

P = 0.215

  1. In bold were marked borderline statistically significant results (P-value < 0.05). No corrections for the multiple statistical testing were made
  2. [GG + GA] versus [AA]—dominant model, risk allele: G
  3. [GG] versus [GA + AA]—recessive model, risk allele: A
  4. *Allele frequencies for the European population according to the 1000Genomes Project have been gathered from http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=9:87450266-87451266;v=rs1867283;vdb=variation;vf=1303363 website
  5. **HWE analysis revealed discordance in the group of females with AB