Table 3 The primary outcome measure of Immediate and sustained treatment response relative to baseline in DH using Schiff cold air sensitivity scale

Immediate

 (Mean scores ± SD)

2.03 ± 0.70

1.34 ± 0.68

1.57 ± 0.81

2.17 ± 0.61

 (p value)^β

< 0.001

< 0.001

< 0.001

0.001

 Percent change from baseline (%)

18.1

45.7

37.6

15.2

Day 3

 (Mean scores ± SD)

1.91 ± 0.73

1.81 ± 0.59

1.81 ± 0.53

2.19 ± 0.60

 (p value)^β

< 0.001

< 0.001

< 0.001

0.003

 Percent change from baseline (%)

22.9

25.5

24.4

10.2

Week 2

 (Mean scores ± SD)

1.25 ± 0.71

1.30 ± 0.58

1.56 ± 0.70

2.12 ± 0.68

(p value)^β

< 0.001

< 0.001

< 0.001

0.001

 Percent change from baseline (%)

48.9

46.9

37.2

14.2

Week 4

 (Mean scores ± SD)

1.03 ± 0.70

1.09 ± 0.62

1.33 ± 0.64

1.91 ± 0.71

 (p value)^β

< 0.001

< 0.001

< 0.001

< 0.001

 Percent change from baseline (%)

58.5

55.8

45.4

22.5

Week 6

 (Mean scores ± SD)

0.97 ± 0.68

0.97 ± 0.68

1.18 ± 0.57

1.82 ± 0.67

 (p value)^β

< 0.001

< 0.001

< 0.001

< 0.001

 Percent change from baseline (%)

61.1

60.1

53.4

25.0