Variable | Model 1, crude model (unadjusted) | Model 2, adjusted for child’s demographic factors | Model 3, adjusted for caregiver factors | Model 4, adjusted for breastfeeding | Model 5, adjusted for oral health behaviors | Model 6, adjusted for all covariates | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PR [95% CI] | P-value | PR [95% CI] | P-value | PR [95% CI] | P-value | PR [95% CI] | P-value | PR [95% CI] | P-value | PR [95% CI] | P-value | |||||||
Main exposure variable | ||||||||||||||||||
Time-averaged fluoride concentration (ppm)* | ||||||||||||||||||
< 0.7 | Reference | Reference | Reference | Reference | Reference | Reference | ||||||||||||
0.7–1.49 | 1.62 [0.78, 3.34] | 0.195 | 1.62 [0.79, 3.32] | 0.190 | 1.61 [0.28, 9.21] | 0.592 | 3.08 [0.47, 20.04] | 0.238 | 3.44 [0.48, 24.62] | 0.218 | 1.64 [0.24, 11.24] | 0.615 | ||||||
≥ 1.5 | 2.75 [1.42, 5.31] | 0.003 | 2.78 [1.45, 5.32] | 0.002 | 2.81 [0.51, 15.51] | 0.235 | 5.30 [0.84, 33.45] | 0.076 | 6.46 [0.94, 44.48] | 0.058 | 2.85 [0.44, 18.52] | 0.273 | ||||||
Child’s demographic factors | ||||||||||||||||||
Sex | ||||||||||||||||||
Female | Reference | Reference | ||||||||||||||||
Male | 1.06 [0.86, 1.29] | 0.596 | 1.07 [0.83, 1.37] | 0.615 | ||||||||||||||
Age (year) | ||||||||||||||||||
< 8 | Reference | Reference | ||||||||||||||||
≥ 8 | 1.19 [0.95, 1.50] | 0.125 | 1.00 [0.75, 1.35] | 0.976 | ||||||||||||||
Caregiver factors | ||||||||||||||||||
Caregiver’s education | ||||||||||||||||||
≥ Secondary school | Reference | Reference | ||||||||||||||||
< Secondary school | 1.25 [0.92, 1.69] | 0.149 | 1.24 [0.91, 1.69] | 0.178 | ||||||||||||||
Sufficiency of family income | ||||||||||||||||||
Sufficient | Reference | Reference | ||||||||||||||||
Insufficient | 0.84 [0.55, 1.30] | 0.442 | 0.81 [0.51, 1.29] | 0.378 | ||||||||||||||
Breastfeeding factor | ||||||||||||||||||
Breastfeeding | ||||||||||||||||||
Yes | Reference | Reference | ||||||||||||||||
No | 1.28 [1.04, 1.57] | 0.019 | 1.31 [0.97, 1.77] | 0.078 | ||||||||||||||
Oral health behaviors | ||||||||||||||||||
Brushing frequency before 2 years old | ||||||||||||||||||
No brushing | Reference | Reference | ||||||||||||||||
Once a day | 1.29 [0.80, 2.08] | 0.303 | 1.24 [0.76, 2.03] | 0.397 | ||||||||||||||
≥ 2 times a day | 0.94 [0.55, 1.59] | 0.805 | 0.95 [0.55, 1.65] | 0.854 | ||||||||||||||
Brushing frequency at ≥ 2 years old | ||||||||||||||||||
Once a day | Reference | Reference | ||||||||||||||||
≥ 2 times a day | 1.18 [0.89, 1.56] | 0.253 | 1.16 [0.83, 1.63] | 0.378 | ||||||||||||||
Fluoride toothpaste use | ||||||||||||||||||
No | Reference | Reference | ||||||||||||||||
Yes | 1.06 [0.68, 1.65] | 0.797 | 1.23 [0.46, 3.28] | 0.685 | ||||||||||||||
Toothpaste size | ||||||||||||||||||
Pea-sized | Reference | Reference | ||||||||||||||||
> Pea-sized | 1.20 [0.96, 1.50] | 0.108 | 1.24 [0.94, 1.63] | 0.130 |