Smoking Cessation therapy is a cost-effective intervention to avoid tooth loss in Brazilian subjects with periodontitis: an economic evaluation

Table 3 States and probabilities used in sensitivity analysis

Deterministic sensitivity analysis
State	Minimum value	Base value	Maximum value
Cost of smoking cessation therapy	185.86	227.41	525.59
Cost of smoking cessation therapy (plus maintenance cost^b)	271.77	227.41	611.50
Cost of periodontal treatment	174.82	194.25	213.68
Cost of maintenance therapy for current smokers	94.80	105.33	115.86
Cost of maintenance therapy for former smokers	47.39	52.66	57.93
Cost of not rehabilitating a tooth loss	12.56	13.95	15.35
Cost of rehabilitating a tooth loss	128.02	142.24	156.46
Discount rate	0.03	0.05	0.07
Probability of smoking cessation with some therapy	0.16^c; 0.23	0.30	0.38
Probability of tooth loss in non-smokers	0.0003	0.003	0.005 (BR)- 0.006#0.09 (WW)
Probability of losing a tooth and not rehabilitate	0.09	0.09	0.41
Utility periodontitis	0.67	0.76	0.89
Utility after periodontal treatment	0.76	0.86	0.96
Utility maintenance therapy	0.85	0.93	0.98
Utility of tooth loss and no rehabilitation	0.55	0.61	0.67
Utility tooth loss and removable partial prothesis	0.62	0.69	0.76
Risk of tooth loss for former smokers	0.98	1.15	1.35
Risk of tooth loss for current smokers	2.29	2.60	2.96, 4.17^c

Probabilistic sensitivity analysis
State	Distribution	Minimum value	Maximum value
Cost of smoking cessation therapy	Triangular	185.86	525.59
Cost of periodontal treatment	Triangular	174.82	213.68
Cost of maintenance therapy for current smokers	Triangular	94.80	115.86
Cost of maintenance therapy for former smokers	Triangular	47.39	57.93
Cost of tooth extraction and not rehabilitate	Triangular	12.56	15.35
Cost of tooth extraction and rehabilitate	Triangular	128.02	156.46
Discount rate	Uniform	0.03	0.07
Probability of smoking cessation with therapy	Triangular	0.23	0.38
Probability of tooth loss in non-smokers	Triangular	0.0007	0.0127
Probability of losing a tooth and not rehabilitate	Triangular	0.07	0.11
Utility periodontitis	Triangular	0.67	0.89
Utility after periodontal treatment	Triangular	0.76	0.96
Utility maintenance therapy	Triangular	0.85	0.98
Utility of tooth loss and no rehabilitation	Triangular	0.55	0.67
Utility tooth loss and removable partial prothesis	Triangular	0.62	0.76

State	Distribution	Mean of logRR^a	Standard Deviation of logRR^a
Risk of tooth loss for former smokers	Normal	0.14	0.28
Risk of tooth loss for current smokers	Normal	0.96	0.27

^alogRR: logarithmic of relative risk
^bIncluding training [34]—For the sensitivity analysis, the global cost/program/year was considered per patient to project a conservative impact of including the therapy in the Public Health System.
^cUsed in deterministic sensitivity analysis. Value extracted from Nohlert E, Tegelberg A, Tillgren P, Johansson P, Rosenblad A, Helgason AR. Comparison of a high and a low intensity smoking cessation intervention in a dentistry setting in Sweden: a randomized trial. BMC Public Health. 2009 Apr 30;9:121. https://doi.org/10.1186/1471-2458-9-121
All costs are in U$ dollar
BR (Brazil); WW (Worldwide)

ISSN: 1472-6831