Skip to main content

Table 2 Seven somatic mutations in four of nine cancer-related genes were seen among short-term khat users diagnosed with OSCC

From: Oral cancer among Khat users: finding evidence from DNA analysis of nine cancer-related gene mutations

Gene

Chromosome

Exon

Nucleotide

Mutation

type

Protein change

Previously reported in other populations

ARID1A

1

20/20

c.5789 C>A

Substitution

p. S1930

Yes

c.5846del A

Deletion

p. H1949fs

Yes

MLH1

3

6/19

c.542_543delGC

Deletion

p. G181D

Yes

PIK3CA

3

9

c.1624G>A

Substitution

p. E542K

Yes

20

c.3140 A>G

Substitution

p. H1047R

Yes

TP53

17

8

c.845G>C

Substitution

p. R150P

Yes

c.856G>A

Substitution

p. E11Q

Yes