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Table 4 Difference in TNF-α parameter for moderately deep pockets (4 mm < PD < 6 mm) and deep pockets (PD > 6 mm)

From: Effect of diode laser combined with minocycline hydrochloride in nonsurgical periodontal therapy: a randomized clinical trial

TNF-α (μg/L)

n (teeth)

Baseline

3 months

p (0–3)

6 months

p (0–6)

p (3–6)

Moderately deep pockets (4 mm < PD < 6 mm)

Con

152

6.51 ± 1.29

4.73 ± 1.20

 < 0.001

4.60 ± 1.11

 < 0.001

0.683

Exp 1

209

6.40 ± 1.20

4.51 ± 1.22

 < 0.001

4.36 ± 0.91

 < 0.001

0.606

Exp 2

211

6.49 ± 1.29

4.43 ± 1.22

 < 0.001

3.84 ± 0.84

 < 0.001

0.037

p

 

0.943

0.605

 

0.002**

0.035

  

Deep pockets (PD > 6 mm)

Con

221

7.12 ± 1.47

5.42 ± 1.15

 < 0.001

5.03 ± 0.99

 < 0.001

0.217

Exp 1

187

7.05 ± 1.43

5.22 ± 0.97

 < 0.001

4.64 ± 0.78

 < 0.001

0.044

Exp 2

213

7.22 ± 1.61

4.67 ± 1.09

 < 0.001

3.94 ± 0.79

 < 0.001

0.017

p

 

0.908

0.007**

 

 < 0.001**

0.002

  
  1. p value refers to the statistically significant difference between groups in the same period (p < 0.05); p (0–3) value refers to the statistically significant difference for each group between baseline and 3 months (p < 0.05); p (0–6) value refers to the statistically significant difference for each group between baseline and 6 months (p < 0.05); p (3–6) value refers to the statistically significant difference for each group between 3 and 6 months (p < 0.05); p value refers to the statistically significant difference between groups in the same period (p < 0.05); **means difference between Con and Exp 2 groups; means difference between Exp 1 and Exp 2 groups