Table 2 Estimated cost per unit and per month of common commercially available oral lichen planus interventions studied in the included randomized controlled trials

Topical steroids

1. Dexamethasone solution

$0.04–0.27 per ml

$77.50

2. Clobetasol ointment

$0.44–7.8 per g

$123.60

3. Clobetasol gel

$0.76–8.33 per g

$136.35

4. Fluocinonide ointment

$0.39–2.68 per g

$46.05

5. Fluocinonide gel

$1.19–3.45 per g

$69.60

6. Triamcinolone ointment

$0.17–0.44 per g

$9.15

7. Triamcinolone paste

$0.30–1.06 per g

$20.40

8. Betamethasone valerate cream

$0.43–0.96 per g

$20.85

9. Fluocinolone acetonide ointment

$0.52–2.91 per g

$51.45

Topical calcineurin inhibitors

1. Tacrolimus ointment

$1.26–8.66 per g

$148.80

2. Tacrolimus cream

$1.13–3.39 per g

$67.80

3. Pimecrolimus cream

$2.06–10.16 per g

$183.30

4. Cyclosporine rinse

$1.83–8.66 per ml

$2622.50

Other topical agents

1. Amlexanox paste (not available in US)

$0.28–1.38 per g

$24.90

2. Isotretinoin gel

$0.63–1.34 per g

$29.55

3. Tazarotene cream

$1.28–3.66 per g

$74.10

4. Tocopherol acetate gel

$0.15–0.27 per g

$6.30

5. Ignatia liquid

$0.14–0.64 per ml

$195.00

6. Aloe vera gel

$0.02–0.06 per g

$1.20

7. Curcumin gel

$1.48–3.18 per g

$69.9

8. Nanocurcumin gel

$0.27–0.45 per g

$10.8

9. S. salivarius K12 lozenge

$0.59–1.13 per lozenge

$51.60

Intralesional therapies

1. Triamcinolone

$10.24–17.00 per ml

$54.48

2. BCG-PSN

$2.67–3.26 per ml

$44.48

Systemic therapies

1. Lycopene

$0.07–0.19 per capsule (4 mg)

$7.80

2. Oral dapsone

$0.73–3.12 per tablet (100 mg)

$115.50

3. Oral betamethasone

$0.52–0.64 per tablet (0.5 mg)

$46.60

Other procedure-directed therapies

1. Photodynamic therapy

$100–4000 per treatment

$16,400.00

2. Low level laser therapy

$30–200 per treatment

$920.00

3. CO2 laser

$450–1450 per treatment

$7600