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Table 1 Characteristics of the included studies evaluating apical leakage

From: Immediate and Delayed Post Space Preparations in Endodontically Treated Teeth: A Scoping Review

Author

(Year)

Sample size

(N)

Groups

System of preparation/Apical size preparation

Filling material / Obturation technique

PSP method

Measurement

Time of immediate PSP

Time of delayed PSP

Outcome

Al-Ashou et al.

(2021) [22]

102

G1:Seal Root / G2:AH Plus /G3:GuttaFlow2

SubGroups: I: 24 h/ II: 1W/ GA: 3mm/ GB: 4mm/ GC: 5mm remaining GP

K3 system/ #40, 0.06

GP/ AH Plus, sure seal root canal sealer, GuttaFlow2/ single-cone technique

Peeso reamer #1-4

Penetration depth of MB dye

24 h

7 days

Delay> immediate

MIN: sure Seal root sealer

3mm>4mm>5mm

Gujarathi et al.

(2021) [26]

60

GA1: AH Plus, imm/ GA2: AH Plus, 1 W/ GB1: sure seal , imm/ GB2: sure seal, 1 W

ProTaper system/

F2

GP/ AH Plus, sure seal root canal sealer / N.r.

Peeso reamer #1-4

depth of dye penetration ,mm, Image Analysis System

Immediately

7 days

Immediate – delay *

sure seal > AH Plus

Tiwari et al.

(2021) [25]

66

G1:AH Plus/ G2: Apexit Plus / G3:Endosequence

SubGroups: A: imm/ B: delay

ProTaper system/

F3

GP/ AH Plus sealer, Apexit Plus sealer, Bioceramic sealer

Heated plugger

Peeso reamer

Penetration depth of MB dye

Immediately

After setting time of the sealers

Delay> immediate

Apexit Plus> AH Plus> Bioceramic

Raslan et al.

(2020) [1]

20

GA: rotary/NO solvent

GB: rotary/ solvent

Mtwo system/

#35

GP/ resin sealer ADSEAL/ WVC

Gates Glidden / solvent (Xylol)

Penetration depth of MB dye in apical third/ stereomicroscope

24 h

7 days

Immediate – delay

GA: immediate-delay

GB: 24h >one week

Tanompetsanga et al

(2020)

60

G1:imm/twisting GP cone

G2:1W/hot plugger

Mtwo system/

50/0.04

GT GP

impregnated + BC particles/ BC Sealer/ single-cone technique

Peeso reamer #3

Fluid filtration device

Immediately

7 days

immediate-delay

Jieqi1 et al.

(2019)

86

GA1:imm,4mm/ GB1:imm,5mm/ GC1: imm,6mm/ GA2:1W,4mm/ GB2:1W,5mm/ GC2:1W,6mm

ProTaper Universal system/

F2

GP/ AH Plus sealer/ LC

N.r..

glucose microleakage model

Immediately

7 days

delay>immediate

IMM: 4mm - 5mm - 6mm

Delay: 4mm > 6mm

Lan Y-y et al.

(2017) [63]

48

GA1: imm, AH-Plus / GB1:1W, AH-Plus/ GA2:imm, MTA/ GB2: 1W, MTA

N.r./ #30

GP/ AH Plus sealer, MTA/ LC

Peeso reamer #3

Apical dye penetration

Immediately

7 days

immediate-delay

AH Plus > MTA

Kim et al.

(2017) [23]

50

GI,G8H, G24H, G72H, & G1W

K3 system/40/0.06

GP/ AH Plus sealer/ WVC

Parapost drill, size 1

Linear penetration of the stain; mm

Immediately

8 h, 24 h, 72h & 7days

G1W>GI,G8H, G24H, G72H

Padmanabhan et al.

(2017) [6]

130

G1:EndoflasFS,imm/ G2:EndoflasFS, 1W/G3: AH Plus, imm/ G4: AHPlus, 1W/ G5:GuttaFlow, imm/ G6:GuttaFlow, 1W/ G7:MTAFillapex, imm/ G8:MTAFillapex,1W

HyFlex CM/

#40/ 0.04%

GP/sealers: Endoflas FS,AH Plus, GuttaFlow ,MTA Fillapex/ single-cone technique

Gates Glidden 1-4

Linear penetration of the stain; mm

Immediately

7 days

delay>immediate

MAX: G2

MIN: G3

G5,G6: immediate-delay

Rui⁃tian et al.

(2016)

30

GA: imm/ GB: 2 days/ GC: 7days

ProTaper system/

F3

GP/ AH Plus sealer/ WVC

Fiber post bur

Apical dye penetration

Immediately

48 h, 7 days

Immediate - delay

Nagas et al.

(2016) [2]

90

G1: GP+ AH Plus/G2: Resilon + Epiphany/G3: Sealite Ultra/

SubGroups: I: single cone/II: CLC/ III: system B

ProFile system/

30,0.06%

GP+ AH Plus or Sealite Ultra, Resilon + Epiphany sealer /single cone; CLC, System B

Gates Glidden

Modified fluid transport test; L/min/cmh2o

Immediately

24 h and

7 days

immediate> delay

Resilon + Epiphany > Sealite Ultra > AH Plus

single cone - CLC - System B

Kala et al.

(2015) [30]

70

G1: imm, EndoREZ sealer /G2: 1W, EndoREZ sealer/ G3:imm, RoekoSeal sealer/ G4: 1W, RoekoSeal sealer/

K3 system/

# 30/ 0.06%

GP/ EndoREZ sealer, RoekoSeal sealer/WVC

peeso reamers 1-4

Linear measurement of the dye penetration / stereomicroscope

Immediately

7 days

Immediate - delay

EndoREZ> RoekoSeal

Pushpa et al.

(2014) [31]

45

G1: imm/ G2: 7days/ G3: 15 days

K-file/

#80

GP/AH Plus/ WVC

heated pluggers Gates Glidden

Apical dye penetration

Immediately

7 days and 15 days

delay>immediate

Dhaded et al.

(2013) [7]

80

G1:AH Plus, imm/ G2:AH Plus, 1W/ G3:Resilon/Epiphany, imm/ G4:Resilon/Epiphany, 1W

Protaper universal/

#40

GP/ AH Plus, Resilon + Epiphany/ CLC

peeso reamer

SEM analysis; mm/ stereomicroscope

Immediately

7 days

delay>immediate

immediately: AH Plus-Resilon + Epiphany

delayed: AH Plus >Resilon/Epiphany

Cheng. Et al

(2013)

100

G1: pulp canal sealer /G2: Tubli-Seal EWT /G3: pulp canal sealer EWT/G4: control

K3 system/

#35

GP/ pulp canal sealer, Tubli-Seal EWT, pulp canal sealer EWT/WVC

heated plugger

Apical dye penetration

Immediately

72h and 7

Days

immediate-delay

pulp canal sealer > Tubli-Seal EWT, pulp canal sealer EWT

Güngör et al

(2013) [34]

44

GA1:GP+AH-Plus imm/ GA2: GP+AH-Plus, 1W/ GE1: EndoREZ, imm/ GE2:EndoREZ, 1W

K-file/

#40

GP/ AH-Plus sealer , EndoREZ /LC

heated pluggers Gates Glidden

computerized fluid filtration

device

Immediately

7 days

GE2> GA1- GE1>GA2

EndoREZ > AH-Plus

Pina-Vaz et al.

(2013)

40

G1: imm, G2: delay

K-file /

N.r.

GP/ Sealapex sealer/ LC

Protaper universal retreatment file

Apical dye penetration

Immediately

8 days

Immediate - delay

Al-Sabawi et al.

(2012) [33]

200

G1: CLC, imm/ G2: single-cone, imm/ G3: CLC, 1W/ G4: single-cone, 1W

SubGroups: heated pluggers, Gates-Glidden, ProTaper rotary, peeso reamers

ProTaper rotary/ F3

GP/ Tgadseal root canal sealer/ CLC, single-cone technique

heated pluggers/

Gates-Glidden/

ProTaper rotary/

peeso reamers

Apical dye penetration

Immediately

7 days

immediate – delay

CLC – single cone technique

Yue et al.

(2012)

55

G1: imm/ G2: 2 days/ G3: 1W

Sub Groups: Post and core preparation after 15, 30 and 60 minutes of cements mixing

K-file/

#40

GP/ N.r. / LC

Gates Glidden/ Peeso reamer

Apical dye penetration

Immediately

48h, 7 days

7days > 2days> immediate

15 - 30 - 60

dezan junior et al.

(2012)

90

Group I (Sealapex, immediately) to Group IX (Topseal, 60 days)

Kerr file/

#60

GP/ Sealapex, Endométhazone, Topseal/ LC

Gates Glidden

Dye infiltration

Immediately

30 days and 60 days

delay>immediate

Type of sealer : no statistical differences

Chen & Chang

(2011) [37]

100

G1: LC / G2: WVC / G3: injectable thermoplasticized GP / G4: control

K3 system/ 0.4 mm

GP/Sealapex / LC ,WVC , injectable thermoplasticized

heated pluggers

Linear penetration of the stain; mm

Immediately

72h and 7

Days

(Immediate, 3 days) > 7 days

Attam & Talwar

(2010) [36]

150

G2: imm, 5mm/ G3: 1W, 5mm/ G4: imm, 3mm/ G5: 1W, 5mm

K3 system/ 45, 0.04%

Epiphany

sealer /Resilon

system/

Peeso reamers 2,3,4

Fluid transport device

Immediately

7 days

delay>immediate

3mm > 5mm

Paiva et al.

(2010) [41]

40

G1: imm, ZOE/ G2: ZOE, delay

N.r.

GP/ ZEO sealer/ LC

ProTaper Universal retreatment files/

H-files

Apical dye penetration

Immediately

8 days

delay>immediate

Aydemir et al.

(2009) [8]

64

G1: CLC, Sealapex, 30 days / G2: CLC, Sealapex, 40 min/ G3: CLC, Diaket, 30 days/ G4: CLC, Diaket,40 min/ G5: WVC, Diaket, 30 days/ G6: WVC, Sealapex, 30 days

K-file/

#50

GP/ Sealapex , Diaket /CLC, WVC

Gates Glidden 1-4

Electrical current; micro-siemens

40 min

30 days

immediate-delay

Sealapex- Diaket

CLC > WVC

Chen Mei et al.

(2009) [44]

60

GA1:imm, temporary materials / GA2:imm,fiber post and cores / GB1: 1W,temporary materials / GB2: 1W,fiber post and cores

hand ProTaper instruments/ F3

GP/ AH Plus/ LC

Peeso reamers #2

Apical dye penetration

Immediately

7 days

delay>immediate

fiber post and core - temporary materials

Kalra et al

(2009) [64]

70

G1: AH-Plus, imm /G2: AH-Plus, 1W/ G3: RC Seal, imm/ G4: RC Seal, 1W

K-file/

#50

GP/ AH-Plus, RC Seal sealer/ E & Q Plus system

Peeso reamers #3

Apical dye penetration

Immediately

7 days

delay>immediate

RC Seal > AH-Plus

Ehsani et al.

(2009) [39]

76

G1: AH26, imm/ G2: AH26, 1W/ G3: Apatite root sealer , imm,/ G4: Apatite root sealer , 1W

K-file/

#35

GP/ AH26, Apatite root sealer / LC

Peeso reamers #3

Apical dye penetration

Immediately

7 days

delay>immediate

AH26 - Apatite root sealer

Yildirim et al.

(2009) [43]

51

G1: GP+AH-Plus+LC , imm / G2: GP+AH-Plus+LC , 1 W/ G3: 5 mm MTA

K-files/

#60

GP/ AH-Plus sealer , MTA plug /LC

heated pluggers

Gates-Glidden

Computerized fluid filtration method

Immediately

7 days

immediate-delay

(GP/ AH-Plus sealer) > MTA

Cobankara et al.

(2008) [38]

50

G1: CLC, EndoREZ (A_), imm / G2: CLC, EndoREZ (A+), imm / G3: CLC, EndoREZ (A_), 1 W/ G4: CLC, EndoREZ (A+),1 W

ProFile system/

0.465 mm

GP/ EndoREZ sealer with or without accelerator / CLC

heated pluggers

Computerized fluid filtration method

Immediately

7 days

delay>immediate

(A+) - (A_)

Salim et al.

(2008) [42]

40

G1a: imm, heated pluggers/ G1b: imm, peeso reamer/ G2a: 1W, heated pluggers/ G2b: 1W, peeso reamer

hand ProTaper instruments/ F1,F2,F3

GP/ Zinc oxide eugenol sealer/ LC

heated pluggers

peeso reamer

Apical dye penetration

Immediately

7 days

delay > immediate

MIN: G1a

MAX: G2b

Corrêa Pesce et al.

(2007) [20]

60

GA1: EndoFill , no post/ GA2: EndoFill, 24 h/ G A3: EndoFill, 72h/ G B1: AH-Plus, no post/ G B2: AH-Plus, 24 h/ G B3: AH-Plus, 72 h

K-file/

#55

GP/

EndoFill or AH-Plus sealer/ CLC

heated pluggers

Apical dye penetration

24 h

72 h

Immediate - delay

EndoFill > AH-Plus

In all groups: 1mm > 2mm >3 mm from the apex

Bodrumlu et al.

(2007) [47]

72

G1:AH Plus, imm/ G2:AH Plus, 1W/ G3:Resilon/Epiphany, imm/ G4:Resilon/Epiphany, 1 W

K-file/

#40

GP/ AH-Plus or Resilon + Epiphany /LC

Gates-Glidden 3-4

Fluid transport device

Immediately

7 days

GP/AH Plus: delay > immediate

Epiphany/Resilon: Immediate > delay

Immediate: (AH-Plus) –(Resilon Epiphany)

Delay:(AH-Plus) > (Epiphany/Resilon)

Shahi et al.

(2007) [51]

96

GA: peeso reamer, imm/ GB: peeso reamer, 1W/ GC: heated pluggers, imm/ GD: heated pluggers, 1W

K-file/

#35

GP/ AH26 sealer/ LC

heated pluggers /peeso reamer

Apical dye penetration

Immediately

7 days

Immediate - delay

MIN: GC

MAX: GB

heated pluggers - peeso reamer

Sadeghi et al.

(2007) [50]

74

G1: LC, imm/G2: LC, 1W/ G3: WVC, imm /G4: WVC, 1W

K-file/

#40

GP/ Tubliseal sealer/ LC, WVC

heated pluggers

Apical dye penetration

Immediately

7 days

delay>immediate

WVC > LC

Javidi et al.

(2007) [49]

76

G1:AH 26, imm/ G2:AH 26, 1W/ G3:Apexit Plus , imm/ G4:Apexit Plus , 1W

K-file/

#45

GP/ AH26 sealer, Apexit Plus / LC

heated pluggers

Apical dye penetration

Immediately

7 days

delay>immediate

G4> G1

AH26 -Apexit Plus

Solano et al.

(2005) [52]

46

G1:AH Plus, imm/ G2:AH Plus, 1W

K3 system/

#30 .06

GP/ AH-Plus sealer/ WVC

heated pluggers / Gates-Glidden

Apical dye penetration

Immediately

7 days

delay>immediate

Rastegar et al.

(2004) [48]

76

G1: AH26, imm/ G2: AH26, 7 days/ G3: Roth sealer, imm/ G4: Roth sealer, 14 days

K-file/

#45

GP/ AH26, Roth sealer/ LC

peeso reamer

Apical dye penetration

Immediately

7 days and 14 days

delay>immediate

MIN: G1

MAX:G4

AH26 - Roth sealer

Ashraf et al.

(2003) [46]

96

G1:imm, AH26/ G2: delay, AH26/ G3: imm, Apexit/ G4: delay, Apexit

K-file/

#40

GP/ AH26, Apexit/ LC

peeso reamer #2,3

Apical dye penetration

Immediately

7 days

Immediate - delay

AH26- Apexit

Abramovitz et al.

(2000) [45]

53

GA:imm/ heated pluggers

GB: 1W/Gates-Glidden 3-4

K-file/

#35

GP/ AH-Plus sealer/ LC

heated pluggers / Gates-Glidden 3-4

Pressure-driven system; cpm, Leakage without Pressure, and Leakage under Pressure

Immediately

7 days

immediate-delay

heated pluggers- drills

Fan et al.

(1999) [55]

90

G1: AH26, imm / G2:AH26, 1W/ G3: Pulp Canal Sealer ,imm/ G4: Pulp Canal Sealer, 1W

K-file/

#50

GP/ AH26 or Pulp Canal Sealer / LC

Gates-Glidden #90

Fluid transport device

Immediately

7 days

delay>immediate

Karapanou et al.

(1996) [56]

80

G1: imm, Roth 801 sealer/ G2:1W, Roth 801 sealer / G3:imm, AH26 / G4:1W, AH26

N.r.

GP/ Roth 801 sealer, AH26/ CLC

Gates-Glidden

Linear penetration of the stain; mm

Immediately

7 days

Roth 801 sealer: delay>immediate

AH-26 sealer: immediate-delay

Rybick & Zillich

(1994) [60]

60

G1: imm, Thermafil / G2:delay, Thermafil / G3:noPSP, Thermafil / G4: no PSP, CLC

K-file/

#35-70

Thermafil, ThermaSeal epoxy resin-based sealer /CLC

Thermafil Prepi burs

Volumetric analysis; absorbance

Immediately

72 h

Immediate - delay

Saunders et al.

(1993) [61]

72

G1: imm/ G2: 1 W

Flex 0 Files/

#40-50

Thermafil/ Sealapex

Peeso reamer #110

Apical dye penetration ; score

Immediately

7 days

Immediate - delay

Moon et al.

(1988) [58]

76

GA1: imm, thermatic condensation/ GA2: delay, LC/ GB1: imm, thermatic condensation/ GB2: delay, LC

H-file/ #25

GP/ AH26 sealer/ thermatic condensation, LC

heated pluggers/ Gates-Glidden/ Peeso reamers

Apical dye penetration

Immediately

7 days

Immediate - delay

LC > Thermatic condensation

Madison & Zakariasen

(1984) [57]

80

G1: imm, solvent/ G2:imm, heat/ G3:imm, drill / G4: 48h, solvent/ G5:48h, heat /G6: 48h, drill/

K-file/

#40

GP/ Roth's root

canal cement/ LC

Peeso reamers/ heated pluggers/ chloroform & files

(Linear penetration of the stain; mm) and (*Volumetric analysis; μl)

Immediately

48h

immediate-delay

solvent - heat – rotary instrument

Portell et al.

(1982) [59]

47

G1: imm, 3mm/ G2: imm, 7mm/ G3: 2 W, 3mm/ G4: 2 W, 7 mm

K-file/

#50

GP/ non staining root canal cement/ CLC

heated pluggers

(Autoradiographic investigation; mm) (Analysis of the incidence; (number teeth with leakage) & degree of leakage: mm)

Immediately

2 week

delay > immediate

3mm > 7mm (At all distances from W.L)

Dickey et al.

(1982) [54]

60

GA1: Peeso reamers, 1 W/ GA2: Peeso reamers, imm/ GB1: solvent, 1 W/ GB2: solvent, imm

K-file/

#55

GP/ Grossman's sealer/ LC

Peeso reamers/ chloroform & files

Autoradiographic investigation; mm

Immediately

7 days

Immediate > delay

solvent - rotary instrument

Bourgeois & Lemon

(1981) [26]

44

GA: delay /GB: imm

N.r.

GP/ AH26 or Grossman's

sealer / LC

heated pluggers

Autoradiographic investigation; mm

Immediately

7 days

Immediate –delay

AH26 > Grossman

  1. (A+)/(A_); with or without accelerator, CLC; cold lateral compaction, G; group, GP; gutta-percha, h; hours, imm; Immediate, L; lateral condensation, MB; methylene blue, mm; millimeter, N.r.; not reported, PSP; post space preparation, W; week, WL; working length, WVC; warm vertical compaction, ZOE; zinc oxide eugenol sealer, - ; similar outcome.