Fig. 6
From: Upregulated Vanins and their potential contribution to periodontitis
Upregulated VNN2 was correlated with neutrophil-related immune response in gingival tissues with periodontitis. A Immunohistochemical staining of MPO, VNN1 and VNN2 in gingival tissues with periodontitis. Positive expression areas of VNN1 and VNN2 were brownish yellow in the connective tissue. Positive expression of MPO was nucleus staining. Scale bar = 100 μm. B Scatter plot showed correlation between positive rate of MPO and that of VNN1 and VNN2 in diseased gingival tissues from periodontitis patients (n = 12). C The Scatter plot showed correlation between AOD of MPO and that of VNN1 and VNN2 in inflamed gingival tissues (n = 12). D Scatter plot showed correlation between VNN2 gene expression and indicators of neutrophil adherence and migration in diseased gingival tissues of periodontitis in two datasets, GSE10334 and GSE16134. Significance was defined in the figure as * p < 0.05, and **** p < 0.0001. AOD, average optical density