Upregulated Vanins and their potential contribution to periodontitis

BMC Oral Health

Table 4 Correlation between VNN2 and indicators of β2 integrin-dependent neutrophil adherence and migration in periodontitis

Gene	Type		GSE10334 (n = 183)		GSE16134 (n = 241)
Gene	Type		R	p	R	p
ITGB2/CD18	Integrin	β2	0.3993****	< 0.0001	0.2649****	< 0.0001
ITGAL/CD11a	Integrin	αL	0.4581****	< 0.0001	0.3063****	< 0.0001
ITGAM/CD11b	Integrin	αM	0.5748****	< 0.0001	0.4660****	< 0.0001
ITGAX/CD11c	Integrin	αX	0.5522****	< 0.0001	0.4769****	< 0.0001
ITGAD/CD11d	Integrin	αD	0.0643	0.3874	0.0358	0.5799
ICAM1	Ligand	ICAM-1	0.0845	0.2556	0.0371	0.5666
ICAM2	Ligand	ICAM-2	0.5122****	< 0.0001	0.4224****	< 0.0001
ICAM3	Ligand	ICAM-3	0.4978****	< 0.0001	0.3983****	< 0.0001
ICAM4	Ligand	ICAM-4	0.4142****	< 0.0001	0.3385****	< 0.0001
ICAM5	Ligand	ICAM-5	0.0623	0.4022	0.0266	0.6813
F11R	Ligand	JAM-1	-0.3305****	< 0.0001	-0.2903****	< 0.0001
JAM3	Ligand	JAM-3	0.0734	0.3233	0.0103	0.8733
AGER	Ligand	RAGE	-0.0695	0.3499	-0.1317*	0.0411
FGA	Ligand	Fibrinogen	0.0694	0.3507	0.1180	0.0674
FGB	Ligand	Fibrinogen	0.1198	0.1063	0.0721	0.2647
FGG	Ligand	Fibrinogen	-0.2677***	0.0002	-0.2179***	0.0007
PLAUR	Ligand	uPAR	0.2739***	0.0002	0.2040**	0.0015
LAMC1	Ligand	Laminin 8	0.3070****	< 0.0001	0.2647****	< 0.0001
VCAM1	Ligand	VCAM1	0.2536***	0.0005	0.2056**	0.0013

Statistical significance was indicated as * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001

ISSN: 1472-6831