Author (year) | No. of teeth (group) | Teeth dropout (n) | Follow-up (month) | Clinical success (n) | Response to cold and electric pulp test (n) | Radiographic assessment and standardization | Results |
---|---|---|---|---|---|---|---|
Ragab et al. (2019)[35] | BC (11) | 0 | 12 | NR | NR | 2D radiographs | Both groups showed radiographic evidence of periapical healing and calcific bridges either cervical and /or apical |
 | BC + PRF (11) | 0 |  |  |  | Image J software | Treatment outcomes did not differ significantly between BC and PRF scaffold |
ElSheshtawy et al. (2020)[36] | PRP (14) | 1 | 18 | No (12) | Positive (0), Negative (13) | 2D radiographs | Changes in RL*, RDT**, AFW***, RRA^ and PAD^^ over time significant in both groups |
 | BC (17) | 0 |  | No (16) | Positive (0), Negative (17) | CBCT | No difference between the PRP and BC groups, using both radiographic and CBCT methods |
 |  |  |  |  |  | Image J |  |
Rizk et al. (2020)[40] | PRP (13) | 0 | 12 | No (13) | Positive (0), Negative (13) | 2D radiographs | Compared with BC, PRP-treated teeth showed statistically significant increases in radiographic root length, width, and periapical bone density, and a decrease in apical diameter |
 | BC + collagen (13) | 0 |  | No (13) | Positive (0), Negative (13) | Image J software |  |
Ramachandran et al. (2020)[37] | BC + PRP(20) | 16 | 06-Dec | No (10) | Positive (0), Negative (10) | 2D radiographs | No difference in the percentage changes in RRA^ between the BC and BC + PRP groups |
 | BC (20) |  |  | No (14) | Positive (0), Negative (14) | Image J software |  |
Meschi et al. (2021)[43] | BC (18) | 4 | 36 | No (14) | Positive (4), Negative (10) | 2D radiographs | Volume root hard tissue thickness and apical area significantly better in the BC than in the BC + L-PRF group |
 | BC + LPRF (11) | 2 |  | No (9) | Positive (5), Negative (4) | CBCT | No significant differences in root length and maximum root hard tissue thickness between the BC and LPRF groups |
 |  |  |  |  |  | Image J software |  |
Cheng et al. (2022)[42] | BC (32) | 0 | Jun-69 | 50 together# | NR | 2D radiographs | Scaffold was a significant predictor of success; BC had a significantly reduced risk for failure than CGF, the induced bleeding technique appeared more appropriate for the management of traumatized teeth with REPs |
 | CGF (30) | 0 |  |  |  | Image J software |  |