Table 6 Clinical and radiographic outcomes of treatment and control groups after 12–18 months (meta)
Author (year) | No. of teeth (group) | No. of teeth drop out | Outcomes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Clinical success (n) | Response to cold and electric pulp test (n) | Periapical healing | Apex closure | Root lengthening | Root canal thickening | |||||||
Excellent + Good | Satisfactory (unsuccessful) | Excellent + Good | Satisfactory (no change) | Excellent + Good | Satisfactory (no change) | Excellent + Good | Satisfactory (no change) | |||||
Jadhav et al. (2012)[12] | 10 (PRP) | 0 | No (10) | NR | 9 | 1 | 10 | 0 | 9 | 1 | 8 | 2 |
| Â | 10 (BC) | 0 | No (10) | NR | 7 | 3 | 5 | 5 | 6 | 4 | 3 | 7 |
Bezgin et al. (2015)[14] | 10 (PRP) | 0 | No (10) | Positive (5), Negative (5) | 7** | 0 | 7 | 3 | & | & | & | & |
| Â | 10 (BC) | 0 | No (10) | Positive (2), Negative (8) | 8** | 0 (1) | 6 | 4 | Â | Â | Â | Â |
Narang et al. (2015)[15] | 5 (PRP) | 0 | No (5) | NR | 4 | 1 | 3 | 2 | 2 | 3 | 1 | 4 |
| Â | 5 (PRF) | 0 | No (5) | Â | 5 | 0 | 2 | 3 | 5 | 0 | 5 | 0 |
| Â | 5 (BC) | 0 | No (5) | Â | 3 | 2 | 3 | 2 | 2 | 3 | 2 | 3 |
Sharma et al. (2016)[32] | 4 (BC) | 0 | No (4) | NR | 3 | 1 | 3 | 1 | 4 | 0 | 2 | 2 |
| Â | 4 (PRF) | 0 | No (4) | Â | 4 | 0 | 4 | 0 | 4 | 0 | 3 | 1 |
| Â | 4 (Collagen) | 0 | No (4) | Â | 4 | 0 | 3 | 1 | 4 | 0 | 3 | 1 |
| Â | 4 (PLGA) | 0 | No (4) | Â | 1 | 3 | 2 | 2 | 4 | 0 | 1 | 3 |
Alag et al. (2017)[16] | 15 (PRP) | 0 | No (15) | Positive (13), Negative (2) | 12*** | 0 | 14 | 1 | # | # | # | # |
| Â | 15 (BC) | 0 | No (15) | Positive (6), Negative (9) | 13*** | 0 | 8 | 7 | Â | Â | Â | Â |
Shivashanker et al. (2017)[33] | 20 (PRF) | 0 | No (20) | Positive (3), Negative (17) | 15 | 3 (2) | 4 | 10 (6) | 6 | 7 (7) | 6 | 8 (6) |
| Â | 20 (PRP) | 1 | No (19) | Positive (3), Negative (16) | 19 | 0 | 4 | 12 (3) | 5 | 9 (5) | 5 | 11 (3) |
| Â | 20 (BC) | 5 | No (15) | Positive (2), Negative (13) | 12 | 3 | 5 | 8 (2) | 4 | 9 (2) | 3 | 11 (1) |
Lv et al. (2018) | 5 (PRF) | 0 | No (5) | Positive (3), Negative (2) | 5 | 0 | 4 | 1 | 4 | 1 | 4 | 1 |
[41] | 5 (BC) | 0 | No (5) | Positive (1), Negative (4) | 5 | 0 | 4 | 1 | 4 | 1 | 4 | 1 |
Mittal et al. (2019)[34] | 4 (PRF) | 0 | No (4) | NR | 3 | 1 | 3 | 1 | 0 | 4 | 4 | 0 |
|  | 4 (BC + collagen) | 0 | No (4) | NR | 4 | 0 | 1 | 3 | 1 | 3 | 3 | 1 |
Ulusoy et al. (2019)[39] | PRP (18) | 4 | No (18) | Positive (13), Negative (5) | 18 | 0 | 10 | 2 (6) | & | & | & | & |
| Â | BC (21) | 1 | No (20) | Positive (20), Negative (1) | 20 | 1 | 15 | 1 (5) | Â | Â | Â | Â |
| Â | PRF (17) | 5 | No (16) | Positive (16), Negative (2) | 16 | 1 | 9 | 5 (3) | Â | Â | Â | Â |
| Â | PP (17) | 5 | No (17) | Positive (16), Negative (2) | 17 | 0 | 7 | 8 (2) | Â | Â | Â | Â |
Uppala et al. (2020)[38] | PRF (8) | 0 | No (8) | NR | 8 | 0 | 8 | 0 | 1 | 7 | 2 | 6 |
| Â | BC (8) | 0 | No (8) | NR | 6 | 2 | 8 | 0 | 6 | 2 | 4 | 4 |
|  | BC + collagen (8) | 0 | No (8) | NR | 8 | 0 | 5 | 3 | 3 | 5 | 2 | 6 |