Trehalose versus carboxymethylcellulose oral spray for relieving radiation-induced xerostomia in head and neck cancer patients: a randomized controlled trial

Table 3 Salivary pH and unstimulated salivary flow rate before and after treatment with CMC and trehalose solution spray

Intervention	Measurement (mean ± SD)	Day of data collection		p-value
Intervention	Measurement (mean ± SD)	Day 0 (Before)	Day 14 (After)	p-value
CMC	Salivary pH	6.78 ± 0.64	6.96 ± 0.7	0.20
CMC	Unstimulated salivary flow rate (mL/min)	0.17 ± 0.16	0.19 ± 0.20	0.146
Trehalose	Salivary pH	6.91 ± 0.67	7.16 ± 0.56	0.033*
Trehalose	Unstimulated salivary flow rate (mL/min)	0.16 ± 0.22	0.20 ± 0.24	0.009**

Paired T-test was used to compare unstimulated salivary flow rate and salivary pH pre- and post-intervention in each treatment group. *p < 0.05; **p < 0.01

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