Table 1 Eligibility Criteria for PACS

* 18 years of age and older

* at least 20 intact natural teeth

* 2 or more lesions, one of which being a cavitated D2 or D3

* willing and able to provide informed consent

Exclusion Criteria

* pregnant or planning to become pregnant during the study (breastfeeding is permitted)

* use of fixed orthodontic appliances

* allergic to any of the ingredients of the study medication (chlorhexidine diacetate, Sumatra benzoin, alcohol, ammonio methacrylate copolymer type B, or triethyl citrate)

* long-term antibiotic therapy (defined as taking an antibiotic -- including low dose doxycycline (Periostat) - for 30 days or more in the past 3 months)

* currently taking any anti-fungal medication prescribed by a doctor or dentist

* a history of, or currently active, radiation therapy for cancers of the head or neck

* Sjögren's syndrome

* advanced periodontitis and in the clinical judgment of the examiner, there is the likelihood the participant will not have 20 natural teeth at the end of the study

* having ten or more teeth requiring restorative care at the time of the screening visit

* requires antibiotic prophylaxis for dental care

* remineralization therapy within one month of randomization (includes use of a fluoride varnish, 5000 ppm prescription fluoride toothpaste, a 0.12% chlorhexidine mouth rinse or gel, sodium fluoride mouth rinse, use of Xylitol products, by mouth, two or more times per day for four or more days per week (excluding Trident)

* investigator discretion