Methodological quality and implications for practice of systematic Cochrane reviews in pediatric oral health: a critical assessment

Smaïl-Faugeron, Violaine; Fron-Chabouis, Hélène; Courson, Frédéric

doi:10.1186/1472-6831-14-35

Table 2 Characteristics of systematic reviews with experimental interventions that had been found effective and should be implemented in practice

From: Methodological quality and implications for practice of systematic Cochrane reviews in pediatric oral health: a critical assessment

Review	Participants	Intervention	Comparator	Outcome	# RCTs	# pts	Relative effect [95% CI]
1830	Permanent teeth in children and adolescents	Resin-based sealant applications on occlusal tooth surfaces of permanent molars	No sealant application	Dentine caries in permanent molars Follow-up: 2 yr	6	1,066	OR 0.12 [0.07;0.19]
2278	Permanent teeth in children and adolescents	Fluoride toothpaste	Placebo	D(M)FS increment - nearest to 3 yr	70	42,300	SMD -0.31 [-0.35;-0.27]
2278	Permanent teeth in children and adolescents	Fluoride toothpaste	Placebo	D(M)FT increment- nearest to 3 yr	53	32,371	SMD -0.28 [-0.33;-0.23]
2279	Permanent and deciduous teeth in children and adolescents	Fluoride varnishes	Placebo/no treatment	D(M)FS increment - nearest to 3 yr	7	2,278	SMD -0.46 [-0.65;-0.26]
2280	Permanent and deciduous teeth in children and adolescents	Fluoride gels	Placebo	D(M)FS increment - nearest to 3 yr	14	4,492	SMD -0.20 [-0.29;-0.10]
2280	Permanent and deciduous teeth in children and adolescents	Fluoride gels	No treatment	D(M)FS increment - nearest to 3 yr	9	2,677	SMD -0.46 [-0.65;-0.27]
2280	Permanent and deciduous teeth in children and adolescents	Fluoride gels	Placebo	D(M)FT increment - nearest to 3 years	4	1,525	SMD -0.19 [-0.29;-0.09]
2280	Permanent and deciduous teeth in children and adolescents	Fluoride gels	No treatment	D(M)FT increment - nearest to 3 years	6	1,673	SMD -0.73 [-1.13;-0.32]
2284	Permanent and deciduous teeth in children and adolescents	Fluoride mouthrinses	Placebo/no treatment	D(M)FS increment - nearest to 3 years	34	14,663	SMD -0.30 [-0.36;-0.24]
2284	Permanent and deciduous teeth in children and adolescents	Fluoride mouthrinses	Placebo/no treatment	D(M)FT increment - nearest to 3 years	13	5,105	SMD -0.28 [-0.37;-0.20]
2782	Permanent and deciduous teeth in children and adolescents	Topical fluoride	Placebo/no treatment	D(M)FS increment - nearest to 3 years	133	65,179	PF 0.26 [0.23;0.29]
2782	Permanent and deciduous teeth in children and adolescents	Topical fluoride	Placebo/no treatment	D(M)FT increment - nearest to 3 yr	79	41,391	PF 0.26 [0.21;0.30]
2782	Permanent and deciduous teeth in children and adolescents	Topical fluoride	Placebo/no treatment	d(e)fs increment - nearest to 3 yr	5	1,685	PF 0.33 [0.22;0.44]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	D(M)FS increment - nearest to 3 yr	74	Not clear	PF 19.79 [16.72;22.87]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	D(M)FT increment - nearest to 3 yr	54	Not clear	PF 21.1 [16.86;25.47]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	D(M)FS increment nearest to 3 yr	74	Not clear	SMD -0.24 [-0.27;-0.20]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	D(M)FT increment - nearest to 3 yr	54	Not clear	SMD -0.24 [-0.28;-0.20]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	d(m)fs increment - nearest to 3 yr	3	Not clear	PF 34.82 [25.68-43.96]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	d(m)ft increment - nearest to 3 yr	3	Not clear	PF 12.18 [5.08-19.29]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	Proportion developing new caries (permanent)	8	Not clear	RR 0.98 [0.94-1.02]
7868	General population of children and adolescents	Fluoride toothpaste	Placebo or other fluoride toothpaste	Proportion developing new caries (deciduous)	3	Not clear	RR 0.87 [0.81-0.93]

Yr, year; #, number; pts, participants; 95% CI, 95% confidence interval; RR: relative risk; OR: odds ratio; SMD: standardized mean difference; PF: prevented fraction = mean caries increment in controls – mean caries increment in the treated group/mean caries increment in controls. D(M)FS increment: caries increment on permanent tooth surfaces; D(M)FT increment: caries increment in permanent teeth; dmfs increment: caries increment on deciduous tooth surfaces; dmft increment: caries increment in deciduous teeth.

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ISSN: 1472-6831

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