From: Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum
Major diagnostic criteria | Minor diagnostic criteria |
---|---|
Radiologically proven osteolytic/-sclerotic bone lesion | Normal blood count and good general state of health |
Multifocal bone lesions | CRP and ESR mildly-to-moderately elevated |
PPP or psoriasis | Observation time longer than 6 months |
Sterile bone biopsy with signs of inflammation and/or fibrosis, sclerosis | Hyperostosis |
Associated with other autoimmune diseases apart from PPP or psoriasis | |
Grade I or II relatives with autoimmune or autoinflammatory disease, or with NBO |