Table 2 Summary comparison of biomarker diagnostic properties for biomarker (miR-155, IL-1β) thresholds between control (C), generalized periodontitis (P), CHD and clinically healthy periodontium (AS-C); and CHD with generalized periodontitis (AS-P) groups
Biomarker | Group Comparisons | Sensitivity | Specificity | Youden Index | AUC | 95% CI | Cut-Off Point | p Value |
|---|---|---|---|---|---|---|---|---|
IL-1β (pg/mL) | C group vs. P group | 100.0% | 95.5% | 0.95 | 1.00 | 1.000–1.000 | > 21.32 | < 0.0001 |
C group vs. AS-C group | 100.0% | 95.5% | 0.95 | 1.00 | 1.000–1.000 | > 21.32 | < 0.0001 | |
C group vs. AS-P group | 100.0% | 95.5% | 0.95 | 1.00 | 1.000–1.000 | > 21.32 | < 0.0001 | |
P group vs. AS-C group | 91.0% | 90.9% | 0.82 | 0.956 | 0.904–1.000 | > 118.6 | < 0.0001 | |
P group vs. AS-P group | 100.0% | 100.0% | 1.00 | 1.00 | 1.000–1.000 | > 144.2 | < 0.0001 | |
AS-C group vs. AS-P group | 100.0% | 95.5% | 0.96 | 1.00 | 1.000–1.000 | > 29.72 | < 0.0001 | |
miR-155(RQ) | C group vs. P group | 76.7% | 53.3% | 0.30 | 0.686 | 0.550–0.821 | > 0.955 | < 0.0001 |
C group vs. AS-C group | 90.0% | 93.3% | 0.83 | 0.958 | 0.914–1.000 | > 2.685 | < 0.0001 | |
C group vs. AS-P group | 100.0% | 97.7% | 0.98 | 0.994 | 0.982–1.000 | > 2.915 | < 0.0001 | |
P group vs. AS-C group | 86.7% | 73.3% | 0.60 | 0.837 | 0.735–0.941 | > 2.820 | < 0.0001 | |
P group vs. AS-P group | 96.7% | 80.0% | 0.77 | 0.957 | 0.915–1.000 | > 3.880 | < 0.0001 | |
AS-C group vs. AS-P group | 80.0% | 50.0% | 0.30 | 0.757 | 0.630–0.880 | > 7.065 | < 0.0006 |