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Table 1 Pathologic reaction scoring system

From: Hard tissue formation in pulpotomized primary teeth in dogs with nanomaterials MCM-48 and MCM-48/hydroxyapatite: an in vivo animal study

Severity of inflammation

 

Score

No inflammation

Absence of neutrophils and lymphocytes

0

Insignificant inflammation

Scattered presence of neutrophils and lymphocytes (< 5%)

1

Mild inflammation

Mild presence of neutrophils and lymphocytes (5–20%)

2

Moderate inflammation

Moderate presence of neutrophils and lymphocytes (20–50%)

3

Severe inflammation

Severe presence of neutrophils and lymphocytes (> 50%)

4

Connective tissue formation

 

Score

Absence of connective tissue

 

0

Granulation tissue

Newly formed tissue comprising numerous capillaries in fine connective tissue and some inflammatory cells

1

Fibrotic tissue

Hyperplasia of fibroblasts along with increased collagen fibers

2

Combination of granulation tissue and fibrotic tissue

 

3

Necrosis

 

Score

Absence of necrosis

 

0

Presence of necrosis

 

1

Severity of edema

 

Score

No

edema

 

0

Mild edema

0–30%

1

Moderate edema

30–60%

2

Severe edema

60–100%

3

Severity of congestion

 

Score

No congestion

1–3 capillaries

0

Mild congestion

3–6 capillaries

1

Moderate congestion

6–10 capillaries

2

Severe congestion

 

3

Osteogenesis

 

Score

Absence of newly formed bone

 

0

Presence of newly formed bone

 

1

Quality of osteogenesis

 

Score

Absence of newly formed bone

 

0

Calcified bone

Deposition of calcium and HA on fibrotic and necrotic tissues

1

Noncompact bone

Newly formed immature bone

2

Compact bone

With the Haversian system and mature bone structure

3

Dentin formation

 

4

Extent of inflammation, connective tissue formation, necrosis, edema, and congestion

Score

None

 

0

Lower third

 

1

Upper two-thirds

 

2

Entire tissue

 

3