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Table 2 p16INK4A and HSV expression presence in connection with clinical diagnosis

From: HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Clinical diagnosis

Number of specimens

p16INK4A expression among the oral lesion (59 total positive)

HSV expression (21 total positive)

HSV + samples co-expressing HPV

Oral lichen planus

30

18 (60.0% OLP)

1 (3.33%)

1 (3.33%)

Leukoplakia

13

7 (53.9% OL)

2 (15.4%)

2 (15.4%)

Mucocele

25

4 (16.0% MUC)

3 (14.3%)

3 (14.3%)

Erosion/ ulceration/ inflammation of mucosa

8

1 (12.5% EUI)

0 (0.0%)

0 (0.0%)

Overgrowth of mucosa

135

29 (21.5% OVG)

15 (11.1%)

15 (11.1%)

  1. χ24 = 25,2 p = 0,00005 for p16INK4A expression
  2. χ28 = 31,1 p = 0,00014 for the HSV expression
  3. OLP oral lichen planus, OL oral leukoplakia, MUC mucocele, EUI Erosion/ ulceration/ inflammation of mucosa, OVG overgrowth of mucosa