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Table 2 Top hub proteins with the highest number of interactions

From: Translating proteome and transcriptome dynamics of periodontal ligament stem cell-derived secretome/conditioned medium in an in vitro model of periodontitis

Gene Name

Protein description

#Interacting proteins

Control vs. LPS

 UBE2C

ubiquitin conjugating enzyme E2C

7

 PBK

PDZ binding kinase

6

 NOTCH2

notch 2

4

 NUF2

NUF2, NDC80 kinetochore complex component

4

 IRS1

insulin receptor substrate 1

4

Control vs. PDLSC-CM

 HSP90AA1

heat shock protein 90 kDa α family, member A1

31

 RPS5

ribosomal protein S5

27

 HRAS

Harvey rat sarcoma viral oncogene homolog

27

 BYSL

bystin like

27

 NOP58

NOP58 ribonucleoprotein

26

LPS vs. LPS + PDLSC-CM

 HSPA5

heat shock protein family A (Hsp70) member 5

11

 BUB1B

BUB1 mitotic checkpoint serine /threonine kinase B

9

 TPR

translocated promoter region, nuclear basket protein

9

 HIST2H2AC

histone cluster 2, H2ac

9

 ASPM

abnormal spindle microtubule assembly

8