Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review

Elhamouly, Yasmine; Adham, May M.; Dowidar, Karin M L; El Backly, Rania M.

doi:10.1186/s12903-024-04221-w

Table 2 Studies included in the review (arranged alphabetically according to author name)

From: Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review

Author, year	Country	Study design	Sample size	Follow-up duration	Outcome measures	Materials used	Type of exposure	Primary/ Permanent	Pre-operative Pulp Status
Abdelwahab D, 2023 [54]	Egypt	RCT	60	1,3,6,12 months	Clinical and radiographic	Totalfill® BC RRM™ Fast Set Putty and MTA WHITE	Carious	Primary	Reversible pulpitis
Abd Al Gawad R and Hanafy R. 2021 [55]	Egypt	RCT	72	3,6,12 months	Clinical and radiographic	NHA (Straumann Bone Ceramic), MTA, Formocresol	Carious OR traumatic	Primary	Reversible pulpitis
Abdel Maksoud E, 2023 [56]	Egypt	RCT	36	3,6,9,12 months	Clinical, radiographic, microbiological	Hyaluronic Acid, Amniotic Membrane Allograft, Mineral Trioxide Aggregate	Carious	Primary	Reversible pulpitis
Aboul Kheir M et al., 2020 [57]	Egypt	RCT	30	12 months	Clinical and radiographic	Chitosan scaffold, MTA	Carious	Permanent	Irreversible pulpitis
Abuelniel G et al., 2020 [58]	Egypt	RCT	50	18 months	Clinical and radiographic	MTA, Biodentine	Traumatic	Immature anterior permanent teeth	Reversible pulpitis
Abuelniel G et al., 2021 [59]	Egypt	RCT	60	6, 12 and 18 months	Clinical and radiographic	MTA, Biodentine	Carious	Immature permanent teeth	Reversible pulpitis
Airen P et al., 2012 [60]	India	NRS	70	24 months	Clinical and radiographic	MTA, Formocresol	Carious	Primary	Reversible pulpitis
Airsang A et al., 2022 [61]	India	RCT	60	6 months and 1 year	Clinical and radiographic	NeoMTA, Biodentine	Carious	Mature permanent	Irreversible pulpitis
Akcay M et al., 2014 [62]	Turkey	RCT	128	12 months	Clinical and radiographic	Calcium hydroxide, MTA	Carious	Primary	Reversible pulpitis
Aksoy B et al., 2022 [63]	Turkey	RCT	105	2 years (6,12,18 and 24)	Clinical and radiographic	Zinc oxide–eugenol, Calcium hydroxide, MTA	Carious	Primary	Reversible pulpitis
Alacam A, 2017 [64]	Turkey	RCT	54	12 months	Clinical and radiographic	Biodentine, Calcium hydroxide, MTA	Carious	Young permanent molars	Reversible pulpitis
Alajaji N, 2021 [65]	Iran	NRS	469	4 years	Clinical and radiographic	MTA, Ferric sulfate, Biodentine	Carious	Primary	Reversible pulpitis
Alamoudi N et al., 2018 [66]	KSA	RCT	106	3, 6 and 12 months	Clinical and radiographic	Low-level laser, Formocresol	Carious	Primary	Reversible pulpitis
Alamoudi N, 2016 [67]	KSA	RCT	112	6 and 12 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
Aljabban et al., 2021 [133]	Syria	RCT	24	8 weeks	Clinical and histological	MTA, PRF	Sound premolar teeth scheduled for orthodontic extraction	Permanent	Normal pulp
Alnassar I et al., 2023 [68]	Syria	RCT	40	1 week, 3 months, 6 months, 9 months, and 1 year	Clinical and radiographic	MTA, Bioceramic putty	Carious	Primary	Reversible pulpitis
Alzoubi H et al., 2021 [69]	Syria	NRS	35	3, 6, 12 months histological evaluation after 3 months	Clinical and radiographic	Portland cement, MTA	Carious	Primary	Reversible pulpitis
Anandan V et al., 2021 [70]	India	NRS	30	2,4 and 6 months	Clinical and radiographic	Formocresol BioFil-AB Collagen Particles	Carious	Primary	Reversible pulpitis
Aripirala M et al., 2021 [71]	India	RCT	100	12 months	Clinical and radiographic	Simvastatin gel, 940 nm diode laser	Carious	Primary	Reversible pulpitis
Asgary S et al., 2012 [72]	Iran	RCT	413	12 months	Clinical and radiographic	MTA, calcium enriched cement (CEM)	Carious	Permanent	Irreversible pulpitis
Asgary S et al., 2022 [73]	Iran	RCT.	154	2 years and pain was assessed upto one week	Clinical and radiographic	Proroot MTA, CEM	Carious	Permanent	Reversible pulpitis OR Irreversible pulpitis
Awad S, 2021 [74]	Egypt	RCT	17	2 years	Clinical and radiographic	Biodentine, Calcium Hydroxide, PRF	Carious	Infected immature permanent molars	NOT MENTIONED
Awawdeh L et al., 2018 [75]	Jordan	RCT	68	3 years	Clinical and radiographic	Biodentine, MTA	Carious	Permanent	Reversible pulpitis
Bakhtiar H et al., 2017 [152]	Iran	RCT	27	8 weeks	Clinical, radiographic, histological	Theracal, Biodentine, proroot MTA	Traumatic	Permanent third molars	Normal pulp
Bakhtiar H et al., 2018 [153]	Iran	RCT	22	1 and 8 weeks	Clinical and histological	Retro-MTA, pro-root MTA	Sound teeth scheduled for extraction	Permanent	Normal pulp
Bani M et al., 2022 [76]	Turkey	RCT	62	24 months	Clinical and radiographic	MTA, Biodentine	Carious	Primary molars	Reversible pulpitis
Bayoumi N, 2022 [77]	Egypt	RCT	40	12 months	Clinical and radiographic	Sterile medicated collagen particles, Biofil-AB, Biodentine	Carious	Primary	Reversible pulpitis
Bhagat D et al., 2017 [154]	India	RCT	30	6 months	Histological	MTA, Portland cement	Traumatic	Premolars scheduled for extraction	Normal pulp
Brar K et al., 2020 [78]	USA	NRS	102	3 years	Clinical and radiographic	Ferric sulfate, Biodentine	Carious	Primary	Reversible pulpitis
Carti O and Oznurhan F, 2017 [79]	Sivas, Turkey	RCT	50	12 months	Clinical and radiographic	Biodentine, MTA	Carious	Primary	Reversible pulpitis
Caruso S et al., 2018 [80]	Italy	NRS	400	9 and 12 months	Clinical and radiographic	Biodentine, Calcium hydroxide	Carious	Primary	Reversible pulpitis
Celik B et al., 2013 [81]	Turkey	RCT	139	24 months	Clinical and radiographic	MTA, Calcium hydroxide	Carious	Primary	Reversible pulpitis
Celik B et al., 2019 [82]	Turkey	RCT	44	3,6,12, 18 and 24 months	Clinical and radiographic	MTA, Biodentine	Carious	Primary	Reversible pulpitis
Chailertvanitkul P et al., 2014 [83]	Thailand	RCT	84	24 months	Clinical and radiographic	MTA, Calcium hydroxide	Carious	Permanent	Reversible pulpitis
Chak R et al., 2022 [84]	India	RCT	60	3, 6, 9, and 12 months	Clinical and radiographic	3Mixtatin, MTA	Carious	Primary	Reversible pulpitis
Chen J, 2017 [85]	USA	RCT	56	6, 9 and 12 months	Clinical and radiographic	MTA, Ferric Sulfate	Carious	Primary molars	Reversible pulpitis
Clancy M, 2018 [86]	USA	RCT	60	2 years with follow-up every 6 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
Cogulu D, 2019 [87]	Turkey	RCT	57	6, 12,18 months	Expression levels of MMP-2, 8 and 9; and clinical and radiographic	MTA, Biodentine	Carious	Primary	Reversible pulpitis
Cordell S, 2019 [88]	USA	RCT	50	6 and 12 months	Clinical and radiographic	NeoMTA, 15.5% ferric sulfate solution	Carious	Primary	Reversible pulpitis
de Lima S et al., 2020 [89]	Brazil	RCT	70	seven days, and at 1, 3, 6 and 12 months	Clinical and radiographic	Bio-C Pulpo, MTA	Carious	Primary	Reversible pulpitis
Eid A et al., 2022 [90]	Syria	RCT	63	12 months	Clinical and radiographic	MTA (MM-MTA), nano-hydroxyapatite, platelet-rich fibrin	Carious	Young permanent molars	Reversible pulpitis
El Meligy O et al., 2016 [155]	KSA	RCT	112	6 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
El Meligy O et al., 2019 [91]	Saudi Arabia	RCT	112	3,6,12 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
Elbardissy A, 2018 [92]	Egypt	RCT	43	3,6,9,12 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
El-desouky S, 2023 [93]	Egypt	RCT	30	6,12 months	Clinical and radiographic	Eggshell Powder freshly mixed with Tea Tree Oil, Biodentine, MTA	Carious	Primary	Reversible pulpitis
Elhamouly Y et al., 2021 [18]	Egypt	Interim analysis /terminated RCT	19	12 months	Clinical, radiographic, histological	Biodentine, bioactive glass	Carious	Primary	Reversible pulpitis
Elheeny A, 2023 [94]	Egypt	RCT	128	12, 18 months	Clinical and radiographic	Simvastatin, MTA	Carious	Immature permanent teeth	Reversible pulpitis
Elsayed S, 2023 [136]	Egypt	RCT	40	3,6 months	Clinical and radiographic	Biofil-AB, Biodentine	Carious	Primary	Reversible pulpitis
Elshaer N, 2021 [95]	Egypt	RCT	40	12 months	Clinical and radiographic	Protooth MTA, MTA	Carious	Primary	Reversible pulpitis
Elshamy SH, 2022 [96]	Egypt	RCT	38	12 months	Clinical and radiographic	Calcium hydroxide, Biodentine	Carious	Young permanent molars	Reversible pulpitis
Eltantawy W, 2023 [97]	Egypt	RCT	96	18 months	Clinical and radiographic	Biodentine, hyaluronic acid, Formocresol	Carious	Primary	Reversible pulpitis
Eshghi A et al., 2022 [98]	Iran	RCT	52	3,6, 9, 12 months	Clinical and radiographic	MTA, Biodentine	Carious	Primary	Reversible pulpitis
Fernandez C et al., 2013 [99]	Spain	RCT	100	24 months	Clinical and radiographic	Formocresol, MTA, ferric sulphate, and NaOCl	Carious	Primary	Reversible pulpitis
Fouad W et al., 2019 [100]	Egypt	NRS	84	12 months	Clinical and radiographic	Biodentine, MTA	Carious	Primary	Reversible pulpitis
Frenkel G et al., 2012 [101]	Israel	NRS	86	47 months	Clinical and radiographic	Ferric Sulphate, MTA	Carious	Primary	Reversible pulpitis
Gaber R et al., 2022 [156]	Egypt	RCT	20	6 months	Clinical and radiographic	MTA, Theracal	Carious	Primary	Reversible pulpitis
Gamal D, 2023 [103]	Egypt	RCT	24	1 year	Clinical and radiographic	Wellroot PT and MTA	Carious	Primary	Reversible pulpitis
Ghent University, 2020 [104]	Belgium	RCT	36	12 months	Clinical and radiographic	Totalfill Bioceramic Root Repair Material®, MTA	Carious	Primary teeth	Reversible pulpitis
Grewal N et al., 2016 [105]	India	RCT	40	12 months	Clinical and radiographic	Biodentine, Calcium hydroxide	Carious	Primary molars	Reversible pulpitis
Guven Y et al., 2016 [106]	Turkey	RCT	116	24 months	Clinical and radiographic	Proroot MTA, MTA-Plus, Biodentine, ferric sulfate	Carious	Primary molars	Reversible pulpitis
Hadassah Medical Organization, 2021 [107]	Israel	NRS	60	36 months	Clinical and radiographic	MedCem MTA, Formocresol	Carious	Primary	Reversible pulpitis
Haideri S et al., 2021 [108]	India	NRS	80	3,6,12 months	Clinical and radiographic	Formocresol, Mineral Trioxide Aggregate, Electrocautery, Bioactive Glass	Carious	Primary	Reversible pulpitis
Hugar S et al., 2017 [109]	India	RCT	60	60 months	Clinical, radiographic, histological	MTA, Formocresol	Carious	Primary	Reversible pulpitis
Ildes G et al., 2022 [110]	Turkey	RCT	130	1,3,6 and 12 months	Clinical and radiographic	0.5% Hyaluronic Acid gel, Formocresol, 20% Ferric sulphate	Carious	Primary molars	Reversible pulpitis
Jayam C et al., 2018 [111]	India	RCT	100	24 months	Clinical and radiographic	MTA, Formocresol	Carious	Primary	Reversible pulpitis
Jimeno F et al., 2022 [112]	Spain	RCT	108	12 months	Clinical and radiographic	MTA ProRoot, MTA HP Repair, Biodentine	Carious	Primary	Reversible pulpitis
Joo Y et al., 2023 [113]	Korea	RCT	153	3, 6, and 12 months	Clinical and radiographic	MTA, Wellroot PT, Proroot MTA	Carious	Primary	Reversible pulpitis
Juneja P and Kulkarni S, 2017 [114]	India	RCT	51	18 months	Clinical and radiographic	MTA, Biodentine, Formocresol	Carious	Primary molars	Reversible pulpitis
Junqueira M et al., 2017 [115]	Brazil	NRS	31	18 months	Clinical and radiographic	MTA and 15.5% Ferric Sulfate	Carious	Primary molars	Reversible pulpitis
Kakarla P et al., 2013 [102]	India	RCT	40	24 months	Histological	Pulpotec, Biofil-AB	Retained sound and indicated for orthodontic extraction	Primary	Reversible pulpitis
Kalra M et al., 2017 [116]	India	RCT	60	12 months	Clinical and radiographic	Fresh Aloe vera barbadensis plant extract, MTA	Carious	Primary molars	Reversible pulpitis
Kang C et al., 2015 [117]	Korea	RCT	151	12 months	Clinical and radiographic	Proroot MTA, OrthoMTA, RetroMTA	Carious	Primary molars	Reversible pulpitis
Kang C et al., 2017 [118]	Korea	RCT	104	1,3,6, and 12 months	Clinical and Radiographic	Proroot MTA, OrthoMTA, RetroMTA	Carious OR traumatic	Permanent	Reversible pulpitis
Kang C et al., 2021 [119]	Korea	RCT	104	1, 3, 6, and 12 months and at 48–78 months	Clinical and radiographic	ProRoot MTA, OrthoMTA, RetroMTA	Carious	Mature permanent teeth	Reversible pulpitis
Kathal S et al., 2017 [120]	India	RCT	40	12 months	Clinical and radiographic	MTA, antioxidant mix	Carious	Primary molars	Reversible pulpitis
Keles S, 2018 [121]	Turkey	RCT	96	3,6, 9 and 18 months	Clinical and radiographic	OrthoMTA, RetroMTA and Ferric sulfate	Carious	Primary	Reversible pulpitis
Keswani D et al., 2014 [122]	India	RCT	70	24 months	Clinical and radiographic	MTA, PRF	Carious	Immature Permanent	Reversible pulpitis
Koruyucu M, 2016 [123]	Turkey	RCT	200	3 years	Clinical and radiographic	ProRoot MTA, Biodentine	Carious	Primary	Reversible pulpitis
Kumar V et al., 2016 [124]	India	RCT	54	12 months	Clinical and radiographic	Calcium hydroxide, MTA, platelet-rich fibrin	Carious	Permanent molars	Irreversible pulpitis
Lourenco N et al., 2016 [157]	Brazil	RCT	25	3 months	Histological and immunohistochemistry	Formocresol, Calcium hydroxide, MTA, Portland cement	Carious	Primary	Reversible pulpitis
Madan K et al., 2020 [125]	India	NRS	40	3,6,12 months	Clinical and radiographic	MTA, propolis	Carious	Primary	Reversible pulpitis
Magdy M, 2020 [126]	Egypt	RCT	36	18 months	Clinical and radiographic	MTA, Biodentine	Carious	Primary	Reversible pulpitis
Mahmoud S, 2022 [127]	Egypt	RCT	130	12 months	Clinical and radiographic	MTA, Formocresol	Carious	Primary teeth	Reversible pulpitis
Manhas M et al., 2019 [135]	India	RCT	30	1,3,6, months	Clinical and radiographic	MTA, Calcium hydroxide, PRF	Carious	Primary	Reversible pulpitis
Manohar S et al., 2022 [21]	India	NRS	120	6, 12, 18, and 24 months	Clinical and radiographic	Biodentine, MTA Plus, Retro MTA, CEM cement	Carious	Primary	Reversible pulpitis
Mehrvarzfar P et al., 2017 [134]	Iran	RCT with histologic assessment	39	6 weeks	Clinical, radiographic, histological	MTA, Treated dentin matrix scaffold	Traumatic	Permanent third molars	Normal pulp
Mentes A, 2020 [22]	Turkey	RCT	120	1,3,6,12 months	Clinical and radiographic	Formocresol, ferric sulphate, and 0.5% hyaluronic acid	Carious	Primary	Reversible pulpitis
Nageh M, 2021 [23]	Egypt	RCT	120	24 h, 48 h, 1 week, every 3 months for 12 months	Clinical and radiographic	Biodentine, PRF, MTA, Portland cement	Carious	Permanent	Irreversible pulpitis
Nagy P, 2017 [24]	Egypt	RCT	22	12 months	Clinical and radiographic	MTA, theracal	Carious	Permanent	NOT MENTIONED
Najmi N, 2022 [25]	Pakistan	RCT	114	12 months	Clinical and radiographic	PRF, MTA, calcium hydroxide	Carious	Mature permanent	Irreversible pulpitis
Neto J, 2017 [167]	Brazil	RCT	30	6 months	Clinical and radiographic	Formocresol, PBS CIMMO cement, Zinc oxide	Carious	Primary	Reversible pulpitis
Nguyen T et al.,2014 [26]	Canada	RCT	48	40 months	Clinical and radiographic	MTA, Ferric sulfate	Carious	Primary	Reversible pulpitis
Nosrat A et al., 2012 [27]	Iran	RCT	51	12 months	Clinical and radiographic	MTA, CEM cement	Carious	Permanent	Irreversible pulpitis
Oliveira T et al., 2013 [28]	Brazil	RCT	45	6,12 and 24 months	Clinical, radiographic, histological	MTA, Calcium hydroxide, Portland cement	Carious	Primary	Reversible pulpitis
Özgür B, et al. 2017 [29]	Turkey	RCT	80	6, 12, 18, and 24 months.	Clinical and radiographic	MTA, calcium hydroxide	Carious	Immature permanent	Reversible pulpitis
Patidar S et al., 2017 [138]	India	RCT	50	6 months	Clinical and radiographic	PRF, MTA	Carious	Primary molars	Reversible pulpitis
Perea M et al., 2017 [30]	Spain	RCT	212	48 months	Clinical and radiographic	Formocresol, MTA	Carious	Primary molars	Reversible pulpitis
Petel R et al., 2021 [31]	Israel	RCT	136	24–48 months	Clinical and radiographic	Formocresol, Portland cement	Carious	Primary	Reversible pulpitis
Prasad M et al., 2017 [139]	India	NRS	30	9 months	Clinical and radiographic	Amniotic, Formocresol	Carious	Primary	Reversible pulpitis
Pratima B et al., 2018 [32]	India	NRS	40	6, 12 months	Clinical and radiographic	Diode laser, MTA	Carious	Primary	Reversible pulpitis
Rajasekharan S et al., 2017 [33]	Belgium	RCT	82	18 months	Clinical and radiographic	Biodentine, proroot MTA	Carious	Primary	Reversible pulpitis
Rao Q et al., 2020 [34]	China	NRS	205	6–8 weeks, 1 year then yearly for 5 years	Clinical and radiographic	iRoot BP Plus, calcium hydroxide	Traumatic	Mature permanent teeth	Reversible pulpitis
Rojaramya K et al., 2022 [35]	India	RCT	60	2 years	Clinical and radiographic	MTA, propolis	Carious	Primary	Reversible pulpitis
Rubanenko M, et al. 2019 [36]	Israel	RCT	72	48 months	Clinical and radiographic	biodentine, Formocresol	Carious	Primary	Reversible pulpitis
Sajadi F et al., 2021 [168]	Iran	RCT	38	3,6, months for clinical and radiographic. pain was evaluated up to 10 days after treatment	Clinical and radiographic	Ferric Sulfate, Calcium-Enriched Mixture Cement (CEM)	Carious	Primary	Reversible pulpitis
Sharaan M and Ali A, 2022 [37]	Egypt	RCT	40	7 days and 3, 6 and 12 months	Clinical and radiographic	MTA, CEM	Carious	Permanent	Irreversible pulpitis
Sharaf R et al., 2021 [150]	Egypt	RCT	90	6 months	Clinical and radiographic	Turmeric extract, Thymus Vulgaris extract, Nigella Sativa extract, aloe vera extract, Formocresol	Carious	Primary	Reversible pulpitis
Sherif R, 2019 [131]	Egypt	RCT	38	12 months	Clinical and radiographic	PRF, Biodentine, diode laser	Carious	Permanent Molars	Irreversible pulpitis
Silva L et al., 2019 [151]	Brazil	RCT	45	3,6 and 12 months	Clinical and radiographic	MTA, Calcium hydroxide, polyethylene glycol	Carious	Primary	Reversible pulpitis
Singh R et al., 2020 [38]	India	NRS	60	12 months	Clinical and radiographic	Calcium hydroxide, MTA, PRF	Carious	Permanent	Irreversible pulpitis
Singh, D et al., 2023 [39]	India	RCT	64	1, 3, 6, and 12 months	Clinical and radiographic	MTA, premixed bioceramic putty	Carious	Mature permanent	Reversible pulpitis
Suez Canal University, 2022 [40]	Egypt	RCT	60	12 months	Clinical and radiographic	Biodentine, Simvastatin	Carious	Primary	Reversible pulpitis
Surinder et al.,2021 [132]	India	RCT	60	9 months	Clinical and radiographic	MTA, Biodentine, Platelet Rich Fibrin	Carious	Permanent	Irreversible pulpitis
Taha N et al., 2022 [41]	Jordan	RCT	164	6 and 12 months	Clinical and radiographic	Proroot MTA, Biodentine, totalfill	Carious	Permanent	Reversible pulpitis OR Irreversible pulpitis
Taha N, 2017 [42]	Jordan	RCT	150	6 m, 1 year then yearly for 5 years	Clinical and radiographic	MTA, Biodentine, non-specified Bioceramic	Carious	Permanent	Reversible pulpitis OR Irreversible pulpitis
Togaru H et al., 2016 [43]	India	RCT	90	12 months	Clinical and radiographic	Biodentine, MTA	Carious	Primary molars	Reversible pulpitis
Tozar K and Almaz M, 2019 [44]	Turkey	RCT	90	12 months	Clinical and radiographic	Laser, MTA	Carious	Immature permanent	Reversible pulpitis
Tzanetakis G et al., 2023 [45]	Greece	RCT	137	7days-2 years	Clinical and radiographic	MTA, Total Fill BC	Carious	Mature permanent	Irreversible pulpitis
Uesrichai N et al., 2019 [46]	Thailand	Non-inferiority RCT	69	every 6 m for mean follow up of 32.2 +/-17.9 months	Clinical and radiographic	Biodentine, Proroot MTA	Carious	Permanent	Irreversible pulpitis
Université de Montréal, 2016 [47]	Canada	RCT	180	12 months	Clinical and radiographic	Biodentine, Formocresol	Carious	Primary	Reversible pulpitis
Vafaeia A et al., 2022 [48]	Iran	NRS	316	28.2 ± 2.7 months	Clinical and radiographic	Protooth calcium silicate cement, MTA	Carious	Immature permanent teeth	Reversible pulpitis
Venugopal N et al., 2019 [137]	India	RCT	90	6 months	Clinical, radiographic, histological	Formocresol, propolis, Platelet derived growth factor (PDGF)/scaffold	Carious	Primary molars	Reversible pulpitis
Vilella-Pastor S et al., 2021 [49]	Spain	RCT	84	6,12,18,24 months	Clinical and Radiographic	MTA, Biodentine	Carious OR traumatic	Primary	Reversible pulpitis
Vu T et al., 2020 [50]	Vietnam	NRS	50	12 months	Clinical and radiographic	Acemannan, MTA	Carious OR traumatic	Permanent	Reversible pulpitis
Wassel M, 2019 [51]	Egypt	RCT	60	12 months	Clinical and radiographic	Theracal, Formocresol	Carious	Primary	Reversible pulpitis
Yang Y et al., 2020 [52]	China	RCT	110	1, 3, 6, 12, 18 and 24 months	Clinical and Radiographic	iRoot BP Plus, Calcium hydroxide	Traumatic	Immature permanent	Reversible pulpitis
Yildirim C et al., 2016 [53]	Turkey	NRS	140	24 months	Clinical and radiographic	Formocresol, MTA, Portland cement, enamel matrix derivative	Carious	Primary	Reversible pulpitis

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