Genome-wide association Scan of dental caries in the permanent dentition

BMC Oral Health

Table 1 Description of the five cohorts

Cohort Description^*	COHRA	DRDR1	DRDR2	ARIC	HPFS
PI	Marazita	Vieira & Marazita	Vieira	Boerwinkle	Hu
Sample Size ^†	970	223	290	4230	1730 (male)
Age ^§	34.3 ± 9.4	41.9 ± 16.9	41.8 ± 17.9	63.1 ± 5.6	65.2 ± 8.4
Age Range	17-67	17-84	17-89	53-75	49-83
Caries Prevalence (%)	95.3	94.5	97.7	99.5	98.7
Caries Phenotype ^¶	DMFS	DMFS	DMFS	Proportion DFS	Caries Severity
Genotyping Platform	Illumina 610-Quad	Illumina 610-Quad	Illumina 610-Quad	Affymetrix 6.0	Affymetrix 6.0
Genotyping Cente ^**	CIDR	CIDR	PITT-GPCL	BICGA	BICGA
Imputed data	Y	Y	N	Y	N

* COHRA: Center for Oral Health Research in Appalachia cohort.
DRDR1: Dental Registry and DNA Repository cohort phase 1.
DRDR2: Dental Registry and DNA Repository cohort phase 2.
ARIC: Atherosclerosis Risk in Community cohort.
HPFS: Health Professionals Follow-Up Study cohort.
† All summary statistics and subsequent analyses only include genotyped non-Hispanic Whites.
§ Mean ± SD.
¶ DMFS: Decayed, Missing due to Decay, or Filled tooth surfaces.
Proportion DFS: Decayed or Filled tooth surfaces / total surfaces at risk.
Caries severity: total # of caries coded as 0, 1; 2–4; 5–9 and 10 or more.
** CIDR: the Johns-Hopkins Center for Inherited Disease Research;
PITT-GPCL: Genomics and Proteomics Core Laboratories at University of Pittsburgh.
BICGA: Broad Institute Center for Genotyping and Analysis at Harvard and MIT.

ISSN: 1472-6831