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Table 1 Characteristics of the studies included in the meta-analysis

From: Association between polymorphism of TGFA Taq I and cleft Lip and/or palate: a meta-analysis

Author, year

Country

Ethnicity

Clip type

Control characteristics

No. (case/control)

Case

Control

      

C1C1

C1C2

C2C2

C1/C2

C1C1

C1C2

C2C2

C1/C2

BEATY [31]

USA

Caucasian

CP

HB

42/135

-

-

-

78/6

-

-

-

248/22

  

Caucasian

CL/P

HB

86/135

-

-

-

163/9

-

-

-

248/22

  

African

CP

HB

13/135

-

-

-

24/2

-

-

-

248/22

  

African

CL/P

HB

11/135

-

-

-

22/0

-

-

-

248/22

TANABE [15]

Japan

Asian

CL/P

HB

28/73

-

-

-

49/7

-

-

-

129/17

Lilian Jara[21]

Chile

Hispanic

CL/P

HB

39/51

33

6

0

72/6

44

6

1

94/8

Sassani [19]

USA

Caucasian

CL/P

HB

81/84

54

26

1

134/28

70

13

1

153/15

  

Asian

CL/P

HB

6/6

4

2

0

10/2

4

2

0

10/2

  

African

CL/P

HB

10/7

4

5

1

13/7

4

3

0

11/3

Ardinger [12]

USA

Caucasian

CL/P

HB

78/98

59

17

2

135/21

89

8

1

186/10

Shiang [20]

USA

Caucasian

CP

HB

43/170

-

-

-

69/17

-

-

-

311/29

Hwang [22]

USA

Caucasian

CP

HB

69/284

49

20

0

118/20

239

44

1

522/46

  

Caucasian

CL/P

HB

114/284

93

19

2

205/23

239

44

1

522/46

ROMITTI [30]

USA

Caucasian

CP

PB

51/295

41

10*

-

-

235

60*

-

-

  

Caucasian

CL/P

PB

118/295

96

22*

-

-

235

60*

-

-

Hecht [24]

USA

Caucasian

CL/P

UFM

12/13

11

1

0

23/1

10

2

1

22/4

Chenevix [18]

Australia

Caucasian

CL/P

HB

117/113

84

30

3

198/36

94

17

2

205/21

Holder [17]

UK

Caucasian

CL/P

HB

60/60

36

14

5

86/24

55

5

0

115/5

CHENEVIX[29]

Australia

Caucasian

CL/P

HB

96/100

66

27

3

159/33

90

9

1

189/11

Stoll [25]

France

Caucasian

CL/P

HB

98/99

-

-

-

187/10

-

-

-

184/14

  

Caucasian

CP

HB

57/99

-

-

-

104/10

-

-

-

184/14

Christensen [11]

Denmark

Caucasian

CP

PB

65/457

49

15

1

113/17

344

102

11

790/124

  

Caucasian

CL/P

PB

191/457

145

45

1

335/47

344

102

11

790/124

SHAW [6]

USA

Caucasian

CP

PB

114/379

87

27*

-

-

321

58*

-

-

  

Hispanic

CP

PB

35/175

34

1*

-

-

164

11*

-

-

  

African

CP

PB

7/20

6

1*

-

-

18

2*

-

-

  

Caucasian

CL/P

PB

245/379

212

33*

-

-

321

58*

-

-

  

Hispanic

CL/P

PB

103/175

94

9*

-

-

164

11*

-

-

  

African

CL/P

PB

12/20

11

1*

-

-

18

2*

-

-

Beaty [26]

USA

Caucasian

CP

HB

51/87

44

6

1

94/8

79

8

0

166/8

  

Caucasian

CL

HB

26/87

21

5

0

47/5

79

8

0

166/8

  

Caucasian

CL/P

HB

53/87

48

5

0

101/5

79

8

0

166/8

  

African

CP

HB

12/45

10

2

0

22/2

43

2

0

88/2

  

African

CL

HB

2/45

2

0

0

4/0

43

2

0

88/2

  

African

CL/P

HB

10/45

9

1

0

19/1

43

2

0

88/2

Bertoja [34]

Brazil

Hispanic

CL/P

HB

140/142

114

25

1

253/27

121

21

0

263/21

PASSOS-BUENO [32]

Brazil

Hispanic

CL/P

HB

536/385

484

51

1

1019/53

344

41

0

729/41

Lidral [28]

USA

Caucasian

CL/P

PB

182/251

-

-

-

327/37

-

-

-

449/53

  

Caucasian

CP

PB

62/251

-

-

-

109/15

-

-

-

449/53

Lidral [27]

USA

Caucasian

CL/P

PB

652/776

-

-

-

1204/100

-

-

-

1436/116

  

Caucasian

CP

PB

97/776

-

-

-

176/18

-

-

-

1436/116

  1. CL: clip lip, CL/P: clip lip and palate, CP: clip palate, PB: population-based control group, HB: hospital-based control group, UFM: unrelated family members control group.
  2. C1C1, C1C2, C2C2: genotype, C1/C2: allele frequency.
  3. *The sum of C1C2 and C2C2.
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BMC Oral Health

ISSN: 1472-6831

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