Table 2 Studies characteristics
Study | Chand DH et al. 2004 | Nafar M et al. 2003 | Mesa FL et al. 2003 | Nash et al. 1998 | Ramalho et al. 2007 |
|---|---|---|---|---|---|
Participants | 25 (17 m, 8 f) mean age: 17.5 ± 6.06 ys | 25 (16 m, 9 f) mean age: 40 ys (range 15–60) | 40 (? m, ? f) mean age: 41.4 ys (range 24–60) | 17 (12 m, 5 f) mean age : none specified | 20 (f) mean age: 32 ± 3 ys |
Setting | Cleveland Clinic Found., Cincinnati Children's Medical Centre | 2 medical centres in Teheran | University hospital of Granada | None specified | University Ospital of Sao Jose do Rio Preto |
Interventions | A: AZM 500 mg day 1, 250 mg. days 2–5 B: MNZ 45 mg/kg/die, 3 doses daily for 7 days. | (All, during the first visit: SRP + 2 g amoxicillin) A: AZM 500 mg day 1, 250 mg days 2–5 B: placebo for 5 days. C:AZM gel 25% for 7 days. D: placebo for 7 days. | A: MNZ 250 mg 3 times/die for 7 days. B: AZM 500 mg 2 times/die for 7 days. C: placebo 3 times/die for 7 days. | A: placebo for 5 days + (after 2 weeks) AZM 500 mg day 1, 250 mg days 2–5 B: AZM 500 mg day 1, 250 mg days 2–5 + (after 2 weeks) placebo for 5 days | A: oral hygiene program B: oral hygiene program + AZM 500 mg for 3 days |
Study Design | Double Blind RCT | Double Blind RCT | Double Blind RCT | Double Blind RCT | RCT |
Length | 24 weeks | 6 weeks | 4 weeks | 12 weeks | 30–60 days |
Outcomes measures | Pocket Depth (mean), photographs | Bleeding on Probing, GO index, Plaque Length, Pocket Depth, crown length, stent interdental papilla | Morphometric GO index, serum creatinine and creatinine clearance | Pocket Depth, tooth length, length of the interdental papillae to the cementum enamel junction, questionnaire, photographs | Subjective evaluation of oral hygiene (questionnaire), SOHI, GH index |
Results | Baseline GO: A: 12.87 +/- 0.40 mm B:13.13 +/- 0.20 mm After 24 weeks: A: 11.50 +/- 0.14 mm B: 12.23 +/- 0.12 mm | Significantly results only for BOP. Insignificant differences between drug and placebo groups for other parameters | Not statistically significant results | Significant improvement in all 3 types of periodontal measurements after assumption of AZM | Significant improvement of SOHI and GH index in patients in AZM group |