Author & Publication Year | Title | Fluoride Exposure | Study design | Study population | Assessment | Results |
---|---|---|---|---|---|---|
Uysal et al. [30] 2010 | Effects of different topical agents on enamel demineralization around orthodontic brackets: and in vivo an in vitro studya | Unspecified water fluoridation. All groups used non-fluoridated toothpaste. | Single-blind randomized clinical study on the prevention of white spot lesions. | 21 orthodontic patients aged 13–17 years | Enamel microhardness | In vivo results showed no statistical difference between the two topical agents. Both topical agents showed statistically significant difference from the control group after 60 days. |
Topical agents – Tooth Mousse®, Fluoridin N5 5 % (22,600 ppm) sodium fluoride topical gel and control group. Application of Tooth Mousse® or Fluoridin N% gel carried out on teeth with orthodontic brackets scheduled for extraction after 60 days. No application on patients in the control group. | ||||||
Sitthisettapong et al. [31] 2012 | Effect of CPP-ACP paste on dental caries in primary teeth: A randomized trial | Non-fluoridated water. Fluoride toothpaste (1000 ppm) used by both groups. | Double-blind randomized placebo-controlled clinical trial on the prevention of caries in high caries risk pre-school children. Topical agents – Tooth Mousse® or placebo paste. | 296 pre-school children aged 2½ to 3½ years | Caries lesion transitions (regression, stability or progression) using ICDASII and dmfs | No significant difference was observed between Tooth Mousse® group and placebo group after 1 year |
Paste applied every school day by trained teacher, following toothbrushing. | ||||||
Plonka et al. [32] 2013 | A randomized controlled clinical trial comparing a remineralizing paste with an anti-bacterial gel to prevent early childhood caries | Unspecified water fluoridation. Fluoride toothpaste (400 ppm) used by all groups. | Randomized controlled trial comparing Tooth Mousse®, chlorhexidine gel and 0.304 % (400 ppm) fluoride toothpaste for reducing mutans streptococci colonization and preventing early childhood caries. | 622 infants aged 0 to 24 months | Cavitations and white spot lesions of early caries | No significant difference in incidence between the three groups after 24 months. |
Tooth Mousse® and chlorhexidine gel were applied by child’s mother in the evening following toothbrushing. |