Table 1 Gene Ontology enrichment analysis of differentially expressed genes of chronic and refractory in blood and saliva

a) Blood-chronic

Term

Count

P-value

 GO:0006414 ~ translational elongation

11

8.07E-11

 GO:0006412 ~ translation

13

9.52E-08

 GO:0006968 ~ cellular defense response

6

1.42E-05

b) Blood-refractory

Term

Count

P-value

 GO:0006955 ~ immune response

4

3.16E-02

c) Saliva-chronic

Term

Count

P-value

 GO:0042981 ~ regulation of apoptosis

12

2.64E-03

 GO:0043067 ~ regulation of programmed cell death

12

2.85E-03

 GO:0010941 ~ regulation of cell death

12

2.93E-03

 GO:0008202 ~ steroid metabolic process

6

3.90E-03

d) Saliva-refractory

Term

Count

P-value

 GO:0010033 ~ response to organic substance

5

8.71E-03

 GO:0009617 ~ response to bacterium

3

2.13E-02

 GO:0019439 ~ aromatic compound catabolic process

2

2.34E-02

 GO:0008286 ~ insulin receptor signaling pathway

2

4.29E-02

 GO:0045787 ~ positive regulation of cell cycle

2

6.54E-02